Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease

2014
journal article
article
11
cris.lastimport.wos2024-04-09T19:24:11Z
dc.abstract.enIntroduction: Eosinophils contribute to the pathogenesis of inflammatory bowel disease (IBD) in the intestine. Eosinophilic cationic protein (ECP) is one of the most important eosinophilic specific mediators released during activation. The aim of the study was to evaluate the clinical value of serum ECP determination in children with active and inactive IBD and its correlation with disease activity. Material and methods: There were 125 children with IBD (63 with Crohn’s disease - CD, 44 with ulcerative colitis - UC, 18 indeterminate colitis - IC) enrolled in the study. Among them 83 children were in the active phase of the disease, while the remaining 42 were in remission. The control group consisted of 56 healthy children. The ECP was assessed three times in children with active IBD, at baseline and after 2 and 6 weeks of treatment and once in children with inactive IBD and controls using fluoroenzymeimmunoassays. Results: We found elevated ECP at baseline in the total active IBD group when compared to the inactive IBD and control groups, decreasing during treatment. Serum ECP was also elevated in the active UC and CD groups when compared to the inactive UC and CD groups, and correlated with clinical UC and CD activity (R = 0.57 and R = 0.52, p < 0.05, respectively) and duration of the clinical manifestation in UC (R = 0.62, p < 0.05) but not with the disease location in the gastrointestinal tract, or endoscopic and histopathological activity. Conclusions: Evaluation of serum ECP in children with IBD may be useful in disease activity assessment at onset and during the treatment.pl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.cm.date2020-01-07
dc.cm.id69412
dc.contributor.authorWędrychowicz, Andrzej - 133750 pl
dc.contributor.authorTomasik, Przemysław - 133663 pl
dc.contributor.authorPieczarkowski, Stanisław - 133135 pl
dc.contributor.authorKowalska-Duplaga, Kinga - 130356 pl
dc.contributor.authorGrzenda-Adamek, Zofia - 352505 pl
dc.contributor.authorFyderek, Krzysztof - 129406 pl
dc.date.accessioned2020-01-17T08:45:01Z
dc.date.available2020-01-17T08:45:01Z
dc.date.issued2014pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number6pl
dc.description.physical1142-1146pl
dc.description.points25pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume10pl
dc.identifier.doi10.5114/aoms.2013.34415pl
dc.identifier.eissn1896-9151
dc.identifier.issn1734-1922pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/134482
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.eneosinophilic cationic proteinpl
dc.subject.eninflammatory bowel diseasepl
dc.subject.enchildrenpl
dc.subtypeArticlepl
dc.titleClinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel diseasepl
dc.title.journalArchives of Medical Sciencepl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T19:24:11Z
dc.abstract.enpl
Introduction: Eosinophils contribute to the pathogenesis of inflammatory bowel disease (IBD) in the intestine. Eosinophilic cationic protein (ECP) is one of the most important eosinophilic specific mediators released during activation. The aim of the study was to evaluate the clinical value of serum ECP determination in children with active and inactive IBD and its correlation with disease activity. Material and methods: There were 125 children with IBD (63 with Crohn’s disease - CD, 44 with ulcerative colitis - UC, 18 indeterminate colitis - IC) enrolled in the study. Among them 83 children were in the active phase of the disease, while the remaining 42 were in remission. The control group consisted of 56 healthy children. The ECP was assessed three times in children with active IBD, at baseline and after 2 and 6 weeks of treatment and once in children with inactive IBD and controls using fluoroenzymeimmunoassays. Results: We found elevated ECP at baseline in the total active IBD group when compared to the inactive IBD and control groups, decreasing during treatment. Serum ECP was also elevated in the active UC and CD groups when compared to the inactive UC and CD groups, and correlated with clinical UC and CD activity (R = 0.57 and R = 0.52, p < 0.05, respectively) and duration of the clinical manifestation in UC (R = 0.62, p < 0.05) but not with the disease location in the gastrointestinal tract, or endoscopic and histopathological activity. Conclusions: Evaluation of serum ECP in children with IBD may be useful in disease activity assessment at onset and during the treatment.
dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii
dc.cm.date
2020-01-07
dc.cm.id
69412
dc.contributor.authorpl
Wędrychowicz, Andrzej - 133750
dc.contributor.authorpl
Tomasik, Przemysław - 133663
dc.contributor.authorpl
Pieczarkowski, Stanisław - 133135
dc.contributor.authorpl
Kowalska-Duplaga, Kinga - 130356
dc.contributor.authorpl
Grzenda-Adamek, Zofia - 352505
dc.contributor.authorpl
Fyderek, Krzysztof - 129406
dc.date.accessioned
2020-01-17T08:45:01Z
dc.date.available
2020-01-17T08:45:01Z
dc.date.issuedpl
2014
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
6
dc.description.physicalpl
1142-1146
dc.description.pointspl
25
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
10
dc.identifier.doipl
10.5114/aoms.2013.34415
dc.identifier.eissn
1896-9151
dc.identifier.issnpl
1734-1922
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/134482
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
eosinophilic cationic protein
dc.subject.enpl
inflammatory bowel disease
dc.subject.enpl
children
dc.subtypepl
Article
dc.titlepl
Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease
dc.title.journalpl
Archives of Medical Science
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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