Advances in studying phasic dopamine signaling in brain reward mechanisms

2013
journal article
article
dc.abstract.enThe last sixty years of research has provided extraordinary advances of our knowledge of the reward system. Since its discovery as a neurotransmitter by Carlsson and colleagues (1), dopamine (DA) has emerged as an important mediator of reward processing. As a result, a number of electrochemical techniques have been developed to measure DA in the brain. Together, these techniques have begun to elucidate the complex roles of tonic and phasic DA signaling in reward processing and addiction. In this review, we will first provide a guide for the most commonly used electrochemical methods for DA detection and describe their utility in furthering our knowledge about DA's role in reward and addiction. Second, we will review the value of common in vitro and in vivo preparations and describe their ability to address different types of questions. Last, we will review recent data that has provided new mechanistic insight of in vivo phasic DA signaling and its role in reward processing and reward-mediated behavior.pl
dc.affiliationWydział Zarządzania i Komunikacji Społecznej : Instytut Psychologii Stosowanejpl
dc.contributor.authorWickham, Robert J.pl
dc.contributor.authorSolecki, Wojciech - 242123 pl
dc.contributor.authorRathbun, Lizapl
dc.contributor.authorNeugebauer, Nichole M.pl
dc.contributor.authorWightman, R. Markpl
dc.contributor.authorAddy, Nii A.pl
dc.date.accession2016-06-04pl
dc.date.accessioned2014-09-25T14:36:45Z
dc.date.available2014-09-25T14:36:45Z
dc.date.issued2013pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number5pl
dc.description.physical982-999pl
dc.description.publication0,8pl
dc.description.versionostateczna wersja wydawcy
dc.identifier.eissn1945-0508pl
dc.identifier.issn1945-0494pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/1344
dc.identifier.weblinkhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725633/pl
dc.languageengpl
dc.language.containerengpl
dc.rights.licenceInna otwarta licencja
dc.share.typeotwarte czasopismo
dc.subject.endopaminepl
dc.subject.envoltammetrypl
dc.subject.enstriatumpl
dc.subject.enreward-related behaviorpl
dc.subject.enpsychostimulantpl
dc.subject.enreinforcement learningpl
dc.subtypeArticlepl
dc.titleAdvances in studying phasic dopamine signaling in brain reward mechanismspl
dc.title.journalFrontiers in Bioscience (Elite ed.)pl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The last sixty years of research has provided extraordinary advances of our knowledge of the reward system. Since its discovery as a neurotransmitter by Carlsson and colleagues (1), dopamine (DA) has emerged as an important mediator of reward processing. As a result, a number of electrochemical techniques have been developed to measure DA in the brain. Together, these techniques have begun to elucidate the complex roles of tonic and phasic DA signaling in reward processing and addiction. In this review, we will first provide a guide for the most commonly used electrochemical methods for DA detection and describe their utility in furthering our knowledge about DA's role in reward and addiction. Second, we will review the value of common in vitro and in vivo preparations and describe their ability to address different types of questions. Last, we will review recent data that has provided new mechanistic insight of in vivo phasic DA signaling and its role in reward processing and reward-mediated behavior.
dc.affiliationpl
Wydział Zarządzania i Komunikacji Społecznej : Instytut Psychologii Stosowanej
dc.contributor.authorpl
Wickham, Robert J.
dc.contributor.authorpl
Solecki, Wojciech - 242123
dc.contributor.authorpl
Rathbun, Liza
dc.contributor.authorpl
Neugebauer, Nichole M.
dc.contributor.authorpl
Wightman, R. Mark
dc.contributor.authorpl
Addy, Nii A.
dc.date.accessionpl
2016-06-04
dc.date.accessioned
2014-09-25T14:36:45Z
dc.date.available
2014-09-25T14:36:45Z
dc.date.issuedpl
2013
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
5
dc.description.physicalpl
982-999
dc.description.publicationpl
0,8
dc.description.version
ostateczna wersja wydawcy
dc.identifier.eissnpl
1945-0508
dc.identifier.issnpl
1945-0494
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/1344
dc.identifier.weblinkpl
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725633/
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights.licence
Inna otwarta licencja
dc.share.type
otwarte czasopismo
dc.subject.enpl
dopamine
dc.subject.enpl
voltammetry
dc.subject.enpl
striatum
dc.subject.enpl
reward-related behavior
dc.subject.enpl
psychostimulant
dc.subject.enpl
reinforcement learning
dc.subtypepl
Article
dc.titlepl
Advances in studying phasic dopamine signaling in brain reward mechanisms
dc.title.journalpl
Frontiers in Bioscience (Elite ed.)
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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