In vitro cytotoxicity testing of new generation oxazaphosphorines against human histiocytic lymphoma cells

2013
journal article
article
dc.abstract.enOxazaphosphorines belong to a group of alkylating agents. Mafosfamide cyclohexylamine salt (D-17272), 4-hydro-peroxy-cyclophosphamide (D-18864) and glufosfamide (D-19575, β-D-glucose-isophosphoramide mustard) are new generation oxazaphosphorines. The objective of the present study was to compare the cytotoxic action of these oxazaphosphorine compounds against human histiocytic lymphoma U937 cells. The chemical structures of the oxazaphosphorines were responsible for the different responses of U937 cells. The cytotoxic effects of D-17272, D-18864, and D-19575 on U937 cells depended on the agent tested, its dose, and the time intervals after the oxazaphosphorine application. Among the oxazaphosphorine agents, D-18864 appeared to be the most cytotoxic, and D-19575 was characterized by the lowest cytotoxicity. The in vitro cytotoxic activities of the oxazaphosphorines were strongly associated with their cell death inducing potential.pl
dc.affiliationWydział Biologii i Nauk o Ziemi : Instytut Zoologiipl
dc.contributor.authorOpydo-Chanek, Małgorzata - 143661 pl
dc.contributor.authorMazur, Lidia - 130441 pl
dc.contributor.authorStojak, Martapl
dc.date.accession2015-07-01pl
dc.date.accessioned2015-07-01T17:16:16Z
dc.date.available2015-07-01T17:16:16Z
dc.date.issued2013pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number8pl
dc.description.physical615-622pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume51pl
dc.identifier.eissn0975-1009pl
dc.identifier.issn0019-5189pl
dc.identifier.projectROD UJ / Ppl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/11070
dc.identifier.weblinkhttp://nopr.niscair.res.in/bitstream/123456789/20484/1/IJEB%2051%288%29%20615-622.pdfpl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych IN 2.5*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttps://creativecommons.org/licenses*
dc.share.typeotwarte czasopismo
dc.subject.enapoptosis and necrosispl
dc.subject.encell viabilitypl
dc.subject.encytotoxicitypl
dc.subject.enmitochondrial membrane potentialpl
dc.subject.enoxazaphosphorinespl
dc.subject.enU937 cellspl
dc.subject.encell countpl
dc.subtypeArticlepl
dc.titleIn vitro cytotoxicity testing of new generation oxazaphosphorines against human histiocytic lymphoma cellspl
dc.title.journalIndian Journal of Experimental Biologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Oxazaphosphorines belong to a group of alkylating agents. Mafosfamide cyclohexylamine salt (D-17272), 4-hydro-peroxy-cyclophosphamide (D-18864) and glufosfamide (D-19575, β-D-glucose-isophosphoramide mustard) are new generation oxazaphosphorines. The objective of the present study was to compare the cytotoxic action of these oxazaphosphorine compounds against human histiocytic lymphoma U937 cells. The chemical structures of the oxazaphosphorines were responsible for the different responses of U937 cells. The cytotoxic effects of D-17272, D-18864, and D-19575 on U937 cells depended on the agent tested, its dose, and the time intervals after the oxazaphosphorine application. Among the oxazaphosphorine agents, D-18864 appeared to be the most cytotoxic, and D-19575 was characterized by the lowest cytotoxicity. The in vitro cytotoxic activities of the oxazaphosphorines were strongly associated with their cell death inducing potential.
dc.affiliationpl
Wydział Biologii i Nauk o Ziemi : Instytut Zoologii
dc.contributor.authorpl
Opydo-Chanek, Małgorzata - 143661
dc.contributor.authorpl
Mazur, Lidia - 130441
dc.contributor.authorpl
Stojak, Marta
dc.date.accessionpl
2015-07-01
dc.date.accessioned
2015-07-01T17:16:16Z
dc.date.available
2015-07-01T17:16:16Z
dc.date.issuedpl
2013
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
8
dc.description.physicalpl
615-622
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
51
dc.identifier.eissnpl
0975-1009
dc.identifier.issnpl
0019-5189
dc.identifier.projectpl
ROD UJ / P
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/11070
dc.identifier.weblinkpl
http://nopr.niscair.res.in/bitstream/123456789/20484/1/IJEB%2051%288%29%20615-622.pdf
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych IN 2.5
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
https://creativecommons.org/licenses
dc.share.type
otwarte czasopismo
dc.subject.enpl
apoptosis and necrosis
dc.subject.enpl
cell viability
dc.subject.enpl
cytotoxicity
dc.subject.enpl
mitochondrial membrane potential
dc.subject.enpl
oxazaphosphorines
dc.subject.enpl
U937 cells
dc.subject.enpl
cell count
dc.subtypepl
Article
dc.titlepl
In vitro cytotoxicity testing of new generation oxazaphosphorines against human histiocytic lymphoma cells
dc.title.journalpl
Indian Journal of Experimental Biology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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