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In vitro cytotoxicity testing of new generation oxazaphosphorines against human histiocytic lymphoma cells
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In vitro cytotoxicity testing of new generation oxazaphosphorines against human histiocytic lymphoma cells
Bibliographic description
| title: | In vitro cytotoxicity testing of new generation oxazaphosphorines against human histiocytic lymphoma cells |
| author: | Opydo-Chanek Małgorzata  , Mazur Lidia , Stojak Marta |
| journal title: | Indian Journal of Experimental Biology |
| volume: | 51 |
| issue: | 8 |
| date of publication : | 2013 |
| pages: | 615-622 |
| ISSN: |
0019-5189 |
| eISSN: |
0975-1009 |
| URL: |
http://nopr.niscair.res.in/bitstream/123456789/20484/1/IJEB%2051%288%29%20615-622.pdf |
| date accessed: |
2015-07-01 |
| language: | English |
| journal language: | English |
| abstract in English: | Oxazaphosphorines belong to a group of alkylating agents. Mafosfamide cyclohexylamine salt (D-17272), 4-hydro-peroxy-cyclophosphamide (D-18864) and glufosfamide (D-19575, β-D-glucose-isophosphoramide mustard) are new generation oxazaphosphorines. The objective of the present study was to compare the cytotoxic action of these oxazaphosphorine compounds against human histiocytic lymphoma U937 cells. The chemical structures of the oxazaphosphorines were responsible for the different responses of U937 cells. The cytotoxic effects of D-17272, D-18864, and D-19575 on U937 cells depended on the agent tested, its dose, and the time intervals after the oxazaphosphorine application. Among the oxazaphosphorine agents, D-18864 appeared to be the most cytotoxic, and D-19575 was characterized by the lowest cytotoxicity. The in vitro cytotoxic activities of the oxazaphosphorines were strongly associated with their cell death inducing potential. |
| keywords in English: | apoptosis and necrosis, cell viability, cytotoxicity, mitochondrial membrane potential, oxazaphosphorines, U937 cells, cell count |
| affiliation: | Wydział Biologii i Nauk o Ziemi : Instytut Zoologii |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych IN 2.5
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
