Simple view
Full metadata view
Authors
Statistics
Determination of azole antifungal medicines using zero-order and derivative UV spectrophotometry
2009
journal article
article
Journal
Acta Poloniae Pharmaceutica. Drug Research
Author
Ekiert Radosław
Krzek Jan
Volume
66
Number
1
Pages
19-24
ISSN
0001-6837
eISSN
2353-5288
Keywords in English
azole antifungal medicines
zero-order and derivative UV spectrophotometry
pharmaceutical analysis
Access date
2020-07-29
Remarks
Bibliogr. s. 23-24
Language
English
Journal language
Polish
Abstract in English
This paper presents a new methodology of quantitative determination of seven azole antifungal medicines widely used in therapy. Analyses were performed directly by using zero-order (fluconazole), first derivative (bifonazole, clotrimazole, econazole, itraconazole, miconazole) and second derivative (ketoconazole) UV spectrophotometry. Validation of all methods confirms their proper precision (%RSD = 0.47 - 2.86), recovery (98.7 - 101.4) and linearity (r coefficient over 0,999) in concentrations under investigation. The parameters received enable the developed procedure to be used in quantitative and as auxiliary in qualitative pharmaceutical analysis.
Affiliation
Wydział Farmaceutyczny : Zakład Chemii Analitycznej
| dc.abstract.en | This paper presents a new methodology of quantitative determination of seven azole antifungal medicines widely used in therapy. Analyses were performed directly by using zero-order (fluconazole), first derivative (bifonazole, clotrimazole, econazole, itraconazole, miconazole) and second derivative (ketoconazole) UV spectrophotometry. Validation of all methods confirms their proper precision (%RSD = 0.47 - 2.86), recovery (98.7 - 101.4) and linearity (r coefficient over 0,999) in concentrations under investigation. The parameters received enable the developed procedure to be used in quantitative and as auxiliary in qualitative pharmaceutical analysis. | pl |
| dc.affiliation | Wydział Farmaceutyczny : Zakład Chemii Analitycznej | pl |
| dc.contributor.author | Ekiert, Radosław - 147732 | pl |
| dc.contributor.author | Krzek, Jan - 130468 | pl |
| dc.date.accession | 2020-07-29 | pl |
| dc.date.accessioned | 2020-07-29T07:59:50Z | |
| dc.date.available | 2020-07-29T07:59:50Z | |
| dc.date.issued | 2009 | pl |
| dc.date.openaccess | 0 | |
| dc.description.accesstime | w momencie opublikowania | |
| dc.description.additional | Bibliogr. s. 23-24 | pl |
| dc.description.number | 1 | pl |
| dc.description.physical | 19-24 | pl |
| dc.description.publication | 0,41 | pl |
| dc.description.version | ostateczna wersja wydawcy | |
| dc.description.volume | 66 | pl |
| dc.identifier.eissn | 2353-5288 | pl |
| dc.identifier.issn | 0001-6837 | pl |
| dc.identifier.project | ROD UJ / OP | pl |
| dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/243012 | |
| dc.identifier.weblink | https://www.ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/11611 | pl |
| dc.language | eng | pl |
| dc.language.container | pol | pl |
| dc.rights | Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa | * |
| dc.rights.licence | CC-BY-NC | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/legalcode.pl | * |
| dc.share.type | otwarte czasopismo | |
| dc.subject.en | azole antifungal medicines | pl |
| dc.subject.en | zero-order and derivative UV spectrophotometry | pl |
| dc.subject.en | pharmaceutical analysis | pl |
| dc.subtype | Article | pl |
| dc.title | Determination of azole antifungal medicines using zero-order and derivative UV spectrophotometry | pl |
| dc.title.journal | Acta Poloniae Pharmaceutica. Drug Research | pl |
| dc.type | JournalArticle | pl |
| dspace.entity.type | Publication |
dc.abstract.enpl
This paper presents a new methodology of quantitative determination of seven azole antifungal medicines widely used in therapy. Analyses were performed directly by using zero-order (fluconazole), first derivative (bifonazole, clotrimazole, econazole, itraconazole, miconazole) and second derivative (ketoconazole) UV spectrophotometry. Validation of all methods confirms their proper precision (%RSD = 0.47 - 2.86), recovery (98.7 - 101.4) and linearity (r coefficient over 0,999) in concentrations under investigation. The parameters received enable the developed procedure to be used in quantitative and as auxiliary in qualitative pharmaceutical analysis. dc.affiliationpl
Wydział Farmaceutyczny : Zakład Chemii Analitycznej dc.contributor.authorpl
Ekiert, Radosław - 147732 dc.contributor.authorpl
Krzek, Jan - 130468 dc.date.accessionpl
2020-07-29 dc.date.accessioned
2020-07-29T07:59:50Z dc.date.available
2020-07-29T07:59:50Z dc.date.issuedpl
2009 dc.date.openaccess
0 dc.description.accesstime
w momencie opublikowania dc.description.additionalpl
Bibliogr. s. 23-24 dc.description.numberpl
1 dc.description.physicalpl
19-24 dc.description.publicationpl
0,41 dc.description.version
ostateczna wersja wydawcy dc.description.volumepl
66 dc.identifier.eissnpl
2353-5288 dc.identifier.issnpl
0001-6837 dc.identifier.projectpl
ROD UJ / OP dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/243012 dc.identifier.weblinkpl
https://www.ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/11611 dc.languagepl
eng dc.language.containerpl
pol dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa dc.rights.licence
CC-BY-NC dc.rights.uri*
http://creativecommons.org/licenses/by-nc/4.0/legalcode.pl dc.share.type
otwarte czasopismo dc.subject.enpl
azole antifungal medicines dc.subject.enpl
zero-order and derivative UV spectrophotometry dc.subject.enpl
pharmaceutical analysis dc.subtypepl
Article dc.titlepl
Determination of azole antifungal medicines using zero-order and derivative UV spectrophotometry dc.title.journalpl
Acta Poloniae Pharmaceutica. Drug Research dc.typepl
JournalArticle dspace.entity.type
Publication Affiliations
No affiliation
Ekiert, Radosław
Krzek, Jan
* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.
Views
75
Views per month
Views per city
Cairo
12
Kolkata
5
Mumbai
5
Delhi
4
Multan
3
Pune
3
Ashburn
2
Hyderabad
2
Wroclaw
2
Abidjan
1
Downloads
ekiert_krzek_determination_of_azole_antifungal_medicines_using_zero-order_2009.pdf
68
ekiert_krzek_determination_of_azole_antifungal_medicines_using_zero-order_2009.odt
10
Open Access
Loading...
