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Antioxidant activity of -carboline derivatives

2011
journal article
article
Journal
Acta Poloniae Pharmaceutica. Drug Research
Author
Francik Renata

Kazek Grzegorz

Cegła Marek

Stępniewski Marek
Volume
68
Number
2
Pages
185-189
ISSN
0001-6837
eISSN
2353-5288
Keywords in English

-carboline derivatives

oxidative stress

DPPH test

FRAP test

URL
https://www.ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/13464
Access date
2020-07-28
Remarks

Bibliogr. s. 189

Language
English
Journal language
English
Abstract in English

The investigated -carboline derivatives were synthesized to elucidate their activity as 5- and 5- receptor ligands. Compounds containing a carboline ring system belong to a large family of biological active indoles, which are very important for the function of the central nervous system (1). The research was carried out to determine antioxidative or oxidative properties of these derivatives. Analysis of antioxidative capacity as indication of oxidative stress was based on ability to scavenge free radicals by DPPH (free radical scavenging activity test) and FRAP test (2, 3). The results were compared to those of standard substances like vitamin C, trolox, quercetin and curcumin. The research of derivatives of -carboline shows antioxidative activity comparable to vitamin C. Compounds 1, 5 and 6, but only in low concentration, have antioxidative activity. Substance 10 was classified as that with prooxidative activity.

Affiliation
Wydział Chemii : Zakład Chemii NieorganicznejWydział Farmaceutyczny : Zakład Chemii OrganicznejWydział Farmaceutyczny : Zakład Wstępnych Badań FarmakologicznychWydział Farmaceutyczny : Zakład Chemii Bioorganicznej
dc.abstract.enThe investigated $\beta$-carboline derivatives were synthesized to elucidate their activity as 5-$HT_{1A}$ and 5- $HT_{2A}$ receptor ligands. Compounds containing a carboline ring system belong to a large family of biological active indoles, which are very important for the function of the central nervous system (1). The research was carried out to determine antioxidative or oxidative properties of these derivatives. Analysis of antioxidative capacity as indication of oxidative stress was based on ability to scavenge free radicals by DPPH (free radical scavenging activity test) and FRAP test (2, 3). The results were compared to those of standard substances like vitamin C, trolox, quercetin and curcumin. The research of derivatives of $\beta$-carboline shows antioxidative activity comparable to vitamin C. Compounds 1, 5 and 6, but only in low concentration, have antioxidative activity. Substance 10 was classified as that with prooxidative activity.pl
dc.affiliationWydział Chemii : Zakład Chemii Nieorganicznejpl
dc.affiliationWydział Farmaceutyczny : Zakład Chemii Organicznejpl
dc.affiliationWydział Farmaceutyczny : Zakład Wstępnych Badań Farmakologicznychpl
dc.affiliationWydział Farmaceutyczny : Zakład Chemii Bioorganicznejpl
dc.contributor.authorFrancik, Renata - 129384 pl
dc.contributor.authorKazek, Grzegorz - 159986 pl
dc.contributor.authorCegła, Marek - 128972 pl
dc.contributor.authorStępniewski, Marek - 133507 pl
dc.date.accession2020-07-28pl
dc.date.accessioned2020-07-28T09:39:21Z
dc.date.available2020-07-28T09:39:21Z
dc.date.issued2011pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 189pl
dc.description.number2pl
dc.description.physical185-189pl
dc.description.publication0,27pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume68pl
dc.identifier.eissn2353-5288pl
dc.identifier.issn0001-6837pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/242898
dc.identifier.weblinkhttps://www.ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/13464pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.en$\beta$-carboline derivativespl
dc.subject.enoxidative stresspl
dc.subject.enDPPH testpl
dc.subject.enFRAP testpl
dc.subtypeArticlepl
dc.titleAntioxidant activity of $\beta$-carboline derivativespl
dc.title.journalActa Poloniae Pharmaceutica. Drug Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The investigated $\beta$-carboline derivatives were synthesized to elucidate their activity as 5-$HT_{1A}$ and 5- $HT_{2A}$ receptor ligands. Compounds containing a carboline ring system belong to a large family of biological active indoles, which are very important for the function of the central nervous system (1). The research was carried out to determine antioxidative or oxidative properties of these derivatives. Analysis of antioxidative capacity as indication of oxidative stress was based on ability to scavenge free radicals by DPPH (free radical scavenging activity test) and FRAP test (2, 3). The results were compared to those of standard substances like vitamin C, trolox, quercetin and curcumin. The research of derivatives of $\beta$-carboline shows antioxidative activity comparable to vitamin C. Compounds 1, 5 and 6, but only in low concentration, have antioxidative activity. Substance 10 was classified as that with prooxidative activity.
dc.affiliationpl
Wydział Chemii : Zakład Chemii Nieorganicznej
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Chemii Organicznej
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Wstępnych Badań Farmakologicznych
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Chemii Bioorganicznej
dc.contributor.authorpl
Francik, Renata - 129384
dc.contributor.authorpl
Kazek, Grzegorz - 159986
dc.contributor.authorpl
Cegła, Marek - 128972
dc.contributor.authorpl
Stępniewski, Marek - 133507
dc.date.accessionpl
2020-07-28
dc.date.accessioned
2020-07-28T09:39:21Z
dc.date.available
2020-07-28T09:39:21Z
dc.date.issuedpl
2011
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 189
dc.description.numberpl
2
dc.description.physicalpl
185-189
dc.description.publicationpl
0,27
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
68
dc.identifier.eissnpl
2353-5288
dc.identifier.issnpl
0001-6837
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/242898
dc.identifier.weblinkpl
https://www.ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/13464
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
$\beta$-carboline derivatives
dc.subject.enpl
oxidative stress
dc.subject.enpl
DPPH test
dc.subject.enpl
FRAP test
dc.subtypepl
Article
dc.titlepl
Antioxidant activity of $\beta$-carboline derivatives
dc.title.journalpl
Acta Poloniae Pharmaceutica. Drug Research
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations
No affiliation
Francik, Renata
Kazek, Grzegorz
Cegła, Marek
Stępniewski, Marek

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