Molecular mechanisms of epithelial to mesenchymal transition in tumor metastasis

2019
journal article
review article
cris.lastimport.wos2024-04-09T23:30:03Z
dc.abstract.enEpithelial to mesenchymal transition (EMT) is a process where cancer cells lose their epithelial features, the cytoskeletal architecture is re-organized, the cell shape changes and cells activate genes that help to define a mesenchymal phenotype, which leads to an increased cell motility and dissemination of tumor to distant metastatic sites. This review describes different signaling networks between microRNAs and proteins that regulate EMT in tumor growth. Activation of EMT is mediated via a series of paracrine signaling molecules. WNT, TGF-β, NOTCH and SHH signaling pathways play crucial roles in activation of EMT-related transcription factors, such as SNAIL, SLUG, ZEB1/2 or TWIST. Recent data provide evidence that crosstalk between microRNAs, long noncoding RNAs and EMT-transcription factors is a crucial event in EMT regulation. MicroRNAs also affect the level of proteins responsible for cellular contact, adhesion and cytoskeletal proteins, which induces changes in the epithelial to mesenchymal phenotype transition. Understanding those signaling networks may help to identify novel biomarkers or develop new treatment strategies based on microRNA therapeutics in the future.pl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.cm.date2020-12-02
dc.cm.id97492
dc.contributor.authorNieszporek, Artur - 393500 pl
dc.contributor.authorSkrzypek, Klaudia - 103991 pl
dc.contributor.authorAdamek, Grazynapl
dc.contributor.authorMajka, Marcin - 130808 pl
dc.date.accession2020-06-18pl
dc.date.accessioned2020-12-02T10:22:54Zpl
dc.date.available2020-12-02T10:22:54Zpl
dc.date.issued2019pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number4pl
dc.description.physical509-520pl
dc.description.points40pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume66pl
dc.identifier.doi10.18388/abp.2019_2899pl
dc.identifier.eissn1734-154Xpl
dc.identifier.issn0001-527Xpl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/256806
dc.identifier.weblinkhttps://ojs.ptbioch.edu.pl/index.php/abp/article/view/2899pl
dc.languageengpl
dc.language.containerengpl
dc.rightshttp://creativecommons.org/licenses/by-sa/4.0/pl/legalcode*
dc.rights.licenceCC-BY-SA
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enepithelial to mesenchymal transition (EMT)pl
dc.subject.entumorpl
dc.subject.enmetastasispl
dc.subject.enmicroRNApl
dc.subject.entranscription factorspl
dc.subtypeReviewArticlepl
dc.titleMolecular mechanisms of epithelial to mesenchymal transition in tumor metastasispl
dc.title.journalActa Biochimica Polonicapl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T23:30:03Z
dc.abstract.enpl
Epithelial to mesenchymal transition (EMT) is a process where cancer cells lose their epithelial features, the cytoskeletal architecture is re-organized, the cell shape changes and cells activate genes that help to define a mesenchymal phenotype, which leads to an increased cell motility and dissemination of tumor to distant metastatic sites. This review describes different signaling networks between microRNAs and proteins that regulate EMT in tumor growth. Activation of EMT is mediated via a series of paracrine signaling molecules. WNT, TGF-β, NOTCH and SHH signaling pathways play crucial roles in activation of EMT-related transcription factors, such as SNAIL, SLUG, ZEB1/2 or TWIST. Recent data provide evidence that crosstalk between microRNAs, long noncoding RNAs and EMT-transcription factors is a crucial event in EMT regulation. MicroRNAs also affect the level of proteins responsible for cellular contact, adhesion and cytoskeletal proteins, which induces changes in the epithelial to mesenchymal phenotype transition. Understanding those signaling networks may help to identify novel biomarkers or develop new treatment strategies based on microRNA therapeutics in the future.
dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii
dc.cm.date
2020-12-02
dc.cm.id
97492
dc.contributor.authorpl
Nieszporek, Artur - 393500
dc.contributor.authorpl
Skrzypek, Klaudia - 103991
dc.contributor.authorpl
Adamek, Grazyna
dc.contributor.authorpl
Majka, Marcin - 130808
dc.date.accessionpl
2020-06-18
dc.date.accessionedpl
2020-12-02T10:22:54Z
dc.date.availablepl
2020-12-02T10:22:54Z
dc.date.issuedpl
2019
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
4
dc.description.physicalpl
509-520
dc.description.pointspl
40
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
66
dc.identifier.doipl
10.18388/abp.2019_2899
dc.identifier.eissnpl
1734-154X
dc.identifier.issnpl
0001-527X
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/256806
dc.identifier.weblinkpl
https://ojs.ptbioch.edu.pl/index.php/abp/article/view/2899
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
http://creativecommons.org/licenses/by-sa/4.0/pl/legalcode
dc.rights.licence
CC-BY-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
epithelial to mesenchymal transition (EMT)
dc.subject.enpl
tumor
dc.subject.enpl
metastasis
dc.subject.enpl
microRNA
dc.subject.enpl
transcription factors
dc.subtypepl
ReviewArticle
dc.titlepl
Molecular mechanisms of epithelial to mesenchymal transition in tumor metastasis
dc.title.journalpl
Acta Biochimica Polonica
dc.typepl
JournalArticle
dspace.entity.type
Publication

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