This study examines the readiness of a faculty for the social challenges caused by the digital transformation in academia with the use of covariance-based structural equation modeling (CBSEM). Based on the survey results, we have examined the interplay between factors related to digital transformation. The concepts of information literacy and digital literacy related to academic librarianship were used as the basis for the self-efficacy and empowerment necessary to achieve individual success during digital changes in the academic community. We then checked how such a sense of empowerment among academics explains the presence of information culture in this community and different approaches to information management. The factors of information management and information use were presented as affecting a university's institutional readiness for the new requirements of digital transformation from the perspective of governance issues. The findings highlight that information literacy underlies academics' empowerment and a high level of self-efficacy driven by this literacy can also be indirectly translated into the formation of pro-active information culture that strengthens an academic's position in creating information use outcomes and by making them ready for digital transformation. Through information literacy outcomes the academic libraries can turn out to be an important transformative force in terms of digital changes at universities.