A vision to increase the availability of PET diagnosis in low- and medium-income countries by combining a low-cost modular J-PET tomograph with the Ti/Sc generator

2024
journal article
article
dc.abstract.enObjectives: This paper presents the prospects for increasing the availability of PET diagnostics by combining low-cost, lightweight and easily portable modular J-PET with the $^{44}$Ti/$^{44}$Sc generator. Methods: J-PET is constructed based on the low-cost axially arranged plastic scintillators that may enable the construction of PET scanners 5 to 10 times less expensive compared to current PET systems, which are based on crystal scintillators. Development of the radionuclide $^{44}$Ti/$^{44}$Sc generator with the 60-year half-lifetime would enable long-term onsite production of $^{44}$Sc labelled radiopharmaceuticals, eliminating the need for extensive and costly infrastructure typically associated with nuclear medicine. Presently applied $^{68}$Ge/$^{68}$Ga generators with the 270 days half- -lifetime require renewal every year. The $^{44}$Ti/$^{44}$Sc generator could, in principle, be purchased once every half century. Results: The lightweight and portable J-PET scanner, combined with the $^{44}$Ti/$^{44}$Sc generator, can be deployed in remote and underserved regions, thus democratising access to advanced medical-imaging techniques. Conclusions: This novel concept shows the transformative potential of combining innovative J-PET technology with the $^{44}$Ti/$^{44}$Sc generator to make advanced diagnostics more accessible and affordable worldwide, especially benefiting millions of patients in low- and medium-income countries, and driving further innovations in medical imaging.
dc.affiliationWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
dc.contributor.authorMoskal, Paweł - 100401
dc.contributor.authorStępień, Ewa - 161583
dc.contributor.authorKhreptak, Aleksander - 262561
dc.date.accessioned2025-02-04T15:02:55Z
dc.date.available2025-02-04T15:02:55Z
dc.date.createdat2025-02-03T10:15:05Zen
dc.date.issued2024
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.numberSpecial Issue
dc.description.physical55-62
dc.description.versionostateczna wersja wydawcy
dc.description.volume20
dc.identifier.doi10.5604/01.3001.0054.9273
dc.identifier.eissn1896-530X
dc.identifier.issn1895-9091
dc.identifier.urihttps://ruj.uj.edu.pl/handle/item/547005
dc.languageeng
dc.language.containereng
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.typeotwarte czasopismo
dc.subject.enpositron emission tomography
dc.subject.enPET
dc.subject.enmodular J-PET
dc.subject.enscandium
dc.subject.en$^{44}$Ti/$^{44}$Sc generator
dc.subtypeArticle
dc.titleA vision to increase the availability of PET diagnosis in low- and medium-income countries by combining a low-cost modular J-PET tomograph with the $^{44}$Ti/$^{44}$Sc generator
dc.title.journalBio-Algorithms and Med-Systems
dc.typeJournalArticle
dspace.entity.typePublicationen
dc.abstract.en
Objectives: This paper presents the prospects for increasing the availability of PET diagnostics by combining low-cost, lightweight and easily portable modular J-PET with the $^{44}$Ti/$^{44}$Sc generator. Methods: J-PET is constructed based on the low-cost axially arranged plastic scintillators that may enable the construction of PET scanners 5 to 10 times less expensive compared to current PET systems, which are based on crystal scintillators. Development of the radionuclide $^{44}$Ti/$^{44}$Sc generator with the 60-year half-lifetime would enable long-term onsite production of $^{44}$Sc labelled radiopharmaceuticals, eliminating the need for extensive and costly infrastructure typically associated with nuclear medicine. Presently applied $^{68}$Ge/$^{68}$Ga generators with the 270 days half- -lifetime require renewal every year. The $^{44}$Ti/$^{44}$Sc generator could, in principle, be purchased once every half century. Results: The lightweight and portable J-PET scanner, combined with the $^{44}$Ti/$^{44}$Sc generator, can be deployed in remote and underserved regions, thus democratising access to advanced medical-imaging techniques. Conclusions: This novel concept shows the transformative potential of combining innovative J-PET technology with the $^{44}$Ti/$^{44}$Sc generator to make advanced diagnostics more accessible and affordable worldwide, especially benefiting millions of patients in low- and medium-income countries, and driving further innovations in medical imaging.
dc.affiliation
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
dc.contributor.author
Moskal, Paweł - 100401
dc.contributor.author
Stępień, Ewa - 161583
dc.contributor.author
Khreptak, Aleksander - 262561
dc.date.accessioned
2025-02-04T15:02:55Z
dc.date.available
2025-02-04T15:02:55Z
dc.date.createdaten
2025-02-03T10:15:05Z
dc.date.issued
2024
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.number
Special Issue
dc.description.physical
55-62
dc.description.version
ostateczna wersja wydawcy
dc.description.volume
20
dc.identifier.doi
10.5604/01.3001.0054.9273
dc.identifier.eissn
1896-530X
dc.identifier.issn
1895-9091
dc.identifier.uri
https://ruj.uj.edu.pl/handle/item/547005
dc.language
eng
dc.language.container
eng
dc.rights
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.en
positron emission tomography
dc.subject.en
PET
dc.subject.en
modular J-PET
dc.subject.en
scandium
dc.subject.en
$^{44}$Ti/$^{44}$Sc generator
dc.subtype
Article
dc.title
A vision to increase the availability of PET diagnosis in low- and medium-income countries by combining a low-cost modular J-PET tomograph with the $^{44}$Ti/$^{44}$Sc generator
dc.title.journal
Bio-Algorithms and Med-Systems
dc.type
JournalArticle
dspace.entity.typeen
Publication
Affiliations

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