Information about gender of the inventors not very often subject of research in the field of patent statistics. Patent information is available through many databases in different forms. But there I no database which offer information about gender statistics of the inventors of patents. Analytical work in this field is so far limited. This article presents results of comparative analysis in the area of relationship between expenditure in the R&D sector, as changes in the women and men being researchers and patent inventors. The research covered Countries of the Central and Eastern Europe (CEE) belong to the European Union (EU) in the period 1999 -2013. The dynamics of the changes in the proposed characteristics were determined using the average rate of change over time. The research results indicate that the European patent application procedure is still a relatively exclusive path, both in terms of costs and quality.