AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar-Kyoto rats

2020
journal article
article
15
cris.lastimport.wos2024-04-10T02:07:56Z
dc.abstract.enBackground: The chronic mild stress (CMS) procedure is a widely used animal model of depression, and its application in Wistar–Kyoto (WKY) rats has been validated as a model of antidepressant-refractory depression. While not responding to chronic treatment with antidepressant drugs, WKY rats do respond to acute deep brain stimulation (DBS) of the medial prefrontal cortex (mPFC). In antidepressant-responsive strains there is evidence suggesting a role for AMPA subtype of glutamate receptor in the action mechanism of both antidepressants and DBS. Methods: Animals were subjected to CMS for 6 to 8weeks; sucrose intake was monitored weekly and novel object recognition (NOR) test was conducted following recovery from CMS. Wistars were treated chronically with venlafaxine (VEN), while WKY were treated acutely with either DBS, optogenetic stimulation (OGS) of virally-transduced (AAV5-hSyn-ChR2-EYFP) mPFC or ventral hippocampus, or acute intra-mPFC injection of the AMPA receptor positive allosteric modulator CX-516. The AMPA receptor antagonist NBQX was administered, at identical sites in mPFC, immediately following the exposure trial in the NOR. Results: Sucrose intake and NOR were suppressed by CMS, and restored by VEN in Wistars and by DBS, OGS, or CX-516 in WKY. However, OGS of the ventral hippocampal afferents to mPFC was ineffective. A low dose of NBQX selectively blocked the procognitive effect of VEN, DBS and OGS. Conclusions: These results suggest that activation of AMPA receptors in the mPFC represents a common pathway for the antidepressant effects of both conventional (VEN) and novel (DBS, OGS) antidepressant modalities, in both antidepressant responsive (Wistar) and antidepressant-resistant (WKY) rats.pl
dc.affiliationWydział Zarządzania i Komunikacji Społecznej : Instytut Psychologii Stosowanejpl
dc.contributor.authorPapp, Mariuszpl
dc.contributor.authorGruca, Piotrpl
dc.contributor.authorLason, Magdalenapl
dc.contributor.authorLitwa, Ewapl
dc.contributor.authorSolecki, Wojciech - 242123 pl
dc.contributor.authorWillner, Paulpl
dc.date.accession2021-04-20pl
dc.date.accessioned2021-04-20T19:40:06Z
dc.date.available2021-04-20T19:40:06Z
dc.date.issued2020pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number12pl
dc.description.physical1418-1430pl
dc.description.publication0,8pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume34pl
dc.identifier.doi10.1177/0269881120967857pl
dc.identifier.eissn1461-7285pl
dc.identifier.issn0269-8811pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/269414
dc.identifier.weblinkhttps://journals.sagepub.com/doi/pdf/10.1177/0269881120967857pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/legalcode*
dc.share.typeotwarte czasopismo
dc.subject.enchronic mild stresspl
dc.subject.enAMPA receptorspl
dc.subject.enmedial prefrontal cortexpl
dc.subject.endeep brain stimulationpl
dc.subject.enoptogenetic stimulationpl
dc.subject.envenlafaxinepl
dc.subject.enampakinepl
dc.subject.enWistar-Kyoto ratpl
dc.subtypeArticlepl
dc.titleAMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar-Kyoto ratspl
dc.title.journalJournal of Psychopharmacologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T02:07:56Z
dc.abstract.enpl
Background: The chronic mild stress (CMS) procedure is a widely used animal model of depression, and its application in Wistar–Kyoto (WKY) rats has been validated as a model of antidepressant-refractory depression. While not responding to chronic treatment with antidepressant drugs, WKY rats do respond to acute deep brain stimulation (DBS) of the medial prefrontal cortex (mPFC). In antidepressant-responsive strains there is evidence suggesting a role for AMPA subtype of glutamate receptor in the action mechanism of both antidepressants and DBS. Methods: Animals were subjected to CMS for 6 to 8weeks; sucrose intake was monitored weekly and novel object recognition (NOR) test was conducted following recovery from CMS. Wistars were treated chronically with venlafaxine (VEN), while WKY were treated acutely with either DBS, optogenetic stimulation (OGS) of virally-transduced (AAV5-hSyn-ChR2-EYFP) mPFC or ventral hippocampus, or acute intra-mPFC injection of the AMPA receptor positive allosteric modulator CX-516. The AMPA receptor antagonist NBQX was administered, at identical sites in mPFC, immediately following the exposure trial in the NOR. Results: Sucrose intake and NOR were suppressed by CMS, and restored by VEN in Wistars and by DBS, OGS, or CX-516 in WKY. However, OGS of the ventral hippocampal afferents to mPFC was ineffective. A low dose of NBQX selectively blocked the procognitive effect of VEN, DBS and OGS. Conclusions: These results suggest that activation of AMPA receptors in the mPFC represents a common pathway for the antidepressant effects of both conventional (VEN) and novel (DBS, OGS) antidepressant modalities, in both antidepressant responsive (Wistar) and antidepressant-resistant (WKY) rats.
dc.affiliationpl
Wydział Zarządzania i Komunikacji Społecznej : Instytut Psychologii Stosowanej
dc.contributor.authorpl
Papp, Mariusz
dc.contributor.authorpl
Gruca, Piotr
dc.contributor.authorpl
Lason, Magdalena
dc.contributor.authorpl
Litwa, Ewa
dc.contributor.authorpl
Solecki, Wojciech - 242123
dc.contributor.authorpl
Willner, Paul
dc.date.accessionpl
2021-04-20
dc.date.accessioned
2021-04-20T19:40:06Z
dc.date.available
2021-04-20T19:40:06Z
dc.date.issuedpl
2020
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
12
dc.description.physicalpl
1418-1430
dc.description.publicationpl
0,8
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
34
dc.identifier.doipl
10.1177/0269881120967857
dc.identifier.eissnpl
1461-7285
dc.identifier.issnpl
0269-8811
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/269414
dc.identifier.weblinkpl
https://journals.sagepub.com/doi/pdf/10.1177/0269881120967857
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/4.0/legalcode
dc.share.type
otwarte czasopismo
dc.subject.enpl
chronic mild stress
dc.subject.enpl
AMPA receptors
dc.subject.enpl
medial prefrontal cortex
dc.subject.enpl
deep brain stimulation
dc.subject.enpl
optogenetic stimulation
dc.subject.enpl
venlafaxine
dc.subject.enpl
ampakine
dc.subject.enpl
Wistar-Kyoto rat
dc.subtypepl
Article
dc.titlepl
AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar-Kyoto rats
dc.title.journalpl
Journal of Psychopharmacology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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