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Aberrant information flow within resting-state triple network model in schizophrenia : an EEG effective connectivity study
central executive network
default mode network
effective connectivity
EEG
resting-state
schizophrenia
Schizophrenia is a psychiatric disorder with heterogeneous clinical manifestations and complex aetiology. Notably, the triple-network model proposes an interesting framework for investigating abnormal neurocircuit activity at rest in schizophrenia. The present study on 30 chronic schizophrenia individuals and 30 controls aimed to explore the differences in EEG resting state effective connectivity within a triple-network model using source-localization-based Directed Transfer Function. Our findings revealed multiband effective connectivity disturbances within default mode (DMN), central executive (CEN), and salience (SN) networks in schizophrenia. The most significant difference was manifested in a global DMN hyperconnectivity, accompanied by low-band hyperconnectivity and high-band hypoconnectivity in CEN, along with the aberrant information flows in SN. In conclusion, our study presents novel insights into schizophrenia neuropathology, with a particular emphasis on the reversed directionality in information flows between hubs of SN, DMN, and CEN. This may be suggested as a promising biomarker of schizophrenia.
dc.abstract.en | Schizophrenia is a psychiatric disorder with heterogeneous clinical manifestations and complex aetiology. Notably, the triple-network model proposes an interesting framework for investigating abnormal neurocircuit activity at rest in schizophrenia. The present study on 30 chronic schizophrenia individuals and 30 controls aimed to explore the differences in EEG resting state effective connectivity within a triple-network model using source-localization-based Directed Transfer Function. Our findings revealed multiband effective connectivity disturbances within default mode (DMN), central executive (CEN), and salience (SN) networks in schizophrenia. The most significant difference was manifested in a global DMN hyperconnectivity, accompanied by low-band hyperconnectivity and high-band hypoconnectivity in CEN, along with the aberrant information flows in SN. In conclusion, our study presents novel insights into schizophrenia neuropathology, with a particular emphasis on the reversed directionality in information flows between hubs of SN, DMN, and CEN. This may be suggested as a promising biomarker of schizophrenia. | |
dc.affiliation | Wydział Filozoficzny : Instytut Psychologii | |
dc.affiliation | Szkoła Doktorska Nauk Społecznych | |
dc.contributor.author | Adamczyk, Przemysław - 105187 | |
dc.contributor.author | Więcławski, Wiktor | |
dc.contributor.author | Wójcik, Maja | |
dc.contributor.author | Frycz, Sandra - 456304 | |
dc.contributor.author | Panek, Bartłomiej - 216204 | |
dc.contributor.author | Jani, Martin | |
dc.contributor.author | Wyczesany, Mirosław - 126071 | |
dc.date.accessioned | 2025-04-15T07:43:23Z | |
dc.date.available | 2025-04-15T07:43:23Z | |
dc.date.createdat | 2025-03-25T18:03:20Z | en |
dc.date.issued | 2025 | |
dc.date.openaccess | 0 | |
dc.description.accesstime | w momencie opublikowania | |
dc.description.sponsorshipidub | idub_yes | |
dc.description.version | ostateczna wersja wydawcy | |
dc.description.volume | 349 | |
dc.identifier.articleid | 111985 | |
dc.identifier.doi | 10.1016/j.pscychresns.2025.111985 | |
dc.identifier.doidataset | 10.57903/UJ/VWZUOD | |
dc.identifier.issn | 0925-4927 | |
dc.identifier.project | Narodowe Centrum Nauki 2016/23/B/HS6/00286 | |
dc.identifier.project | Narodowe Centrum Nauki 2021/41/B/HS6/02967 | |
dc.identifier.uri | https://ruj.uj.edu.pl/handle/item/551522 | |
dc.language | eng | |
dc.language.container | eng | |
dc.rights | Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa | |
dc.rights.licence | CC-BY | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/legalcode.pl | |
dc.share.type | otwarte czasopismo | |
dc.subject.en | central executive network | |
dc.subject.en | default mode network | |
dc.subject.en | effective connectivity | |
dc.subject.en | EEG | |
dc.subject.en | resting-state | |
dc.subject.en | schizophrenia | |
dc.subtype | Article | |
dc.title | Aberrant information flow within resting-state triple network model in schizophrenia : an EEG effective connectivity study | |
dc.title.journal | Psychiatry Research - Neuroimaging | |
dc.type | JournalArticle | |
dspace.entity.type | Publication | en |