Based on ongoing research on ostracism, and after discussing some conceptual issues, we will attempt to provide insights into the effects of ostracism on people’s well-being as individuals, partners, and group members. Specifically, we will explore (a) individual- and personality-based risk factors of ostracism (intrapersonal level); (b) deprivation of social touch, disruption of empathy, and social stigmatization in interpersonal relations (interpersonal level); and (c) disruption of social identity, social stigmatization, and rise in prejudiced, discriminatory, and xenophobic tendencies within groups (intergroup level). Furthermore, we will attempt to provide a comprehensive argument of how this multi-level conceptualization of ostracism can deepen our understanding of ostracism during the Covidian era. The implications of the interplay between personal and social identity for the measurement of ostracism will also be discussed. Next, a conceptually integrative approach to ostracism will be formulated as well as strategies for tackling ostracism during the pandemic or similar widespread crises. Finally, avenues for future research will be suggested.