Positronium lifetime validation measurements using a long-axial field-of-view positron emission tomography scanner

2024
journal article
article
2
dc.abstract.enPositron emission tomography (PET) traditionally uses coincident annihilation photons emitted from a positron interacting with an electron to localize cancer within the body. The formation of positronium (Ps), a bonded electron-positron pair, has not been utilized in clinical applications of PET due to the need to detect either the emission of a prompt gamma ray or the decay of higher-order coincident events. Assessment of the lifetime of the formed Ps, however, can potentially yield additional diagnostic information of the surrounding tissue because Ps properties vary due to void size and molecular composition. To assess the feasibility of measuring Ps lifetimes with a PET scanner, experiments were performed in a Biograph Vision Quadra (Siemens Healthineers). Quadra is a long-axial field-of-view (LA-FOV) PET scanner capable of producing list-mode data from single interaction events.
dc.affiliationSzkoła Doktorska Nauk Ścisłych i Przyrodniczych
dc.affiliationWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
dc.contributor.authorSteinberger, William M.
dc.contributor.authorMercolli, Lorenzo
dc.contributor.authorBreuer, Johannes
dc.contributor.authorSari, Hasan
dc.contributor.authorParzych, Szymon - 369531
dc.contributor.authorNiedźwiecki, Szymon - 115136
dc.contributor.authorLapkiewicz, Gabriela
dc.contributor.authorMoskal, Paweł - 100401
dc.contributor.authorStępień, Ewa - 161583
dc.contributor.authorRominger, Axel
dc.contributor.authorShi, Kuangyu
dc.contributor.authorConti, Maurizio
dc.date.accessioned2024-10-02T14:22:24Z
dc.date.available2024-10-02T14:22:24Z
dc.date.issued2024
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number1
dc.description.versionostateczna wersja wydawcy
dc.description.volume11
dc.identifier.articleid76
dc.identifier.doi10.1186/s40658-024-00678-4
dc.identifier.eissn2197-7364
dc.identifier.urihttps://ruj.uj.edu.pl/handle/item/449743
dc.languageeng
dc.language.containereng
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.typeotwarte czasopismo
dc.subject.enpositronium imaging
dc.subject.enpositron emission tomography
dc.subject.enmolecular imaging
dc.subtypeArticle
dc.titlePositronium lifetime validation measurements using a long-axial field-of-view positron emission tomography scanner
dc.title.journalEJNMMI Physics
dc.typeJournalArticle
dspace.entity.typePublicationen
dc.abstract.en
Positron emission tomography (PET) traditionally uses coincident annihilation photons emitted from a positron interacting with an electron to localize cancer within the body. The formation of positronium (Ps), a bonded electron-positron pair, has not been utilized in clinical applications of PET due to the need to detect either the emission of a prompt gamma ray or the decay of higher-order coincident events. Assessment of the lifetime of the formed Ps, however, can potentially yield additional diagnostic information of the surrounding tissue because Ps properties vary due to void size and molecular composition. To assess the feasibility of measuring Ps lifetimes with a PET scanner, experiments were performed in a Biograph Vision Quadra (Siemens Healthineers). Quadra is a long-axial field-of-view (LA-FOV) PET scanner capable of producing list-mode data from single interaction events.
dc.affiliation
Szkoła Doktorska Nauk Ścisłych i Przyrodniczych
dc.affiliation
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
dc.contributor.author
Steinberger, William M.
dc.contributor.author
Mercolli, Lorenzo
dc.contributor.author
Breuer, Johannes
dc.contributor.author
Sari, Hasan
dc.contributor.author
Parzych, Szymon - 369531
dc.contributor.author
Niedźwiecki, Szymon - 115136
dc.contributor.author
Lapkiewicz, Gabriela
dc.contributor.author
Moskal, Paweł - 100401
dc.contributor.author
Stępień, Ewa - 161583
dc.contributor.author
Rominger, Axel
dc.contributor.author
Shi, Kuangyu
dc.contributor.author
Conti, Maurizio
dc.date.accessioned
2024-10-02T14:22:24Z
dc.date.available
2024-10-02T14:22:24Z
dc.date.issued
2024
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.number
1
dc.description.version
ostateczna wersja wydawcy
dc.description.volume
11
dc.identifier.articleid
76
dc.identifier.doi
10.1186/s40658-024-00678-4
dc.identifier.eissn
2197-7364
dc.identifier.uri
https://ruj.uj.edu.pl/handle/item/449743
dc.language
eng
dc.language.container
eng
dc.rights
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.en
positronium imaging
dc.subject.en
positron emission tomography
dc.subject.en
molecular imaging
dc.subtype
Article
dc.title
Positronium lifetime validation measurements using a long-axial field-of-view positron emission tomography scanner
dc.title.journal
EJNMMI Physics
dc.type
JournalArticle
dspace.entity.typeen
Publication
Affiliations

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