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First positronium imaging using Sc with the J-PET scanner : a case study on the NEMA-Image Quality phantom

2025
journal article
article
10.1109/TRPMS.2025.3621554
Journal
IEEE Transactions on Radiation and Plasma Medical Sciences
20
Author
Das Manish

Sharma Sushil

Beyene Ermias Yitayew

Bilewicz Aleksander

Choinski Jaroslaw
Show more
Pages
1-11
ISSN
2469-7311
eISSN
2469-7303
Keywords in English

Positronium Lifetime Imaging

PET

NEMA

44Sc

J-PET

medical imaging

positronium imaging

Remarks

Online First 2025-10-14

Language
English
Journal language
English
Abstract in English

Positronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the positronium atom. Currently, the method is under rapid development in terms of reconstruction and detection systems. Recently, the first in vivo PLI of the human brain was performed using the J-PET scanner utilizing the 68Ga isotope. However, this isotope has limitations due to its comparatively low prompt gamma yields, which is crucial for positronium lifetime measurement. Among alternative radionuclides, 44Sc stands out as a promising isotope for PLI, characterized by a clinically suitable half-life (4.04 hours) emitting 1157 keV prompt gamma in 100% cases after the emission of the positron. This study reports the first experimental demonstration of PLI with 44Sc, carried out on a NEMA-Image Quality (IQ) phantom using the Modular J-PET tomograph–the first plastic scintillators-based PET scanner.

Affiliation
Szkoła Doktorska Nauk Ścisłych i PrzyrodniczychWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana SmoluchowskiegoWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Informatyki Stosowanej
dc.abstract.enPositronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the positronium atom. Currently, the method is under rapid development in terms of reconstruction and detection systems. Recently, the first in vivo PLI of the human brain was performed using the J-PET scanner utilizing the 68Ga isotope. However, this isotope has limitations due to its comparatively low prompt gamma yields, which is crucial for positronium lifetime measurement. Among alternative radionuclides, 44Sc stands out as a promising isotope for PLI, characterized by a clinically suitable half-life (4.04 hours) emitting 1157 keV prompt gamma in 100% cases after the emission of the positron. This study reports the first experimental demonstration of PLI with 44Sc, carried out on a NEMA-Image Quality (IQ) phantom using the Modular J-PET tomograph–the first plastic scintillators-based PET scanner.
dc.affiliationSzkoła Doktorska Nauk Ścisłych i Przyrodniczych
dc.affiliationWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
dc.affiliationWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Informatyki Stosowanej
dc.contributor.authorDas, Manish - 478556
dc.contributor.authorSharma, Sushil - 200161
dc.contributor.authorBeyene, Ermias Yitayew - 473796
dc.contributor.authorBilewicz, Aleksander
dc.contributor.authorChoinski, Jaroslaw
dc.contributor.authorChug, Neha - 417025
dc.contributor.authorCurceanu, Catalina
dc.contributor.authorCzerwiński, Eryk - 102850
dc.contributor.authorValsan Eliyan, Kavya - 460040
dc.contributor.authorHajduga, Jakub
dc.contributor.authorJalali, Sharareh - 507854
dc.contributor.authorKacprzak, Krzysztof - 116744
dc.contributor.authorKaplanoglu, Muhammed Tevfik - 477032
dc.contributor.authorKapłon, Łukasz - 115081
dc.contributor.authorKasperska, Kamila - 491314
dc.contributor.authorKhreptak, Aleksander - 262561
dc.contributor.authorKorcyl, Grzegorz - 107362
dc.contributor.authorKozik, Tomasz - 129362
dc.contributor.authorKubat, Karol - 228213
dc.contributor.authorKumar, Deepak - 448421
dc.contributor.authorKunimmal Venadan, Anoop - 497669
dc.contributor.authorLisowski, Edward
dc.contributor.authorLisowski, Filip
dc.contributor.authorMędrala-Sowa, Justyna - 493140
dc.contributor.authorMoyo, Simbarashe - 459890
dc.contributor.authorMryka, Wiktor - 385379
dc.contributor.authorNiedźwiecki, Szymon - 115136
dc.contributor.authorPandey, Piyush - 497670
dc.contributor.authorParzych, Szymon - 369531
dc.contributor.authorPorcelli, Alessio - 509000
dc.contributor.authorRachwal, Bartlomiej
dc.contributor.authorPerez del Rio, Elena - 444273
dc.contributor.authorRädler, Martin - 489637
dc.contributor.authorRominger, Axel
dc.contributor.authorShi, Kuangyu
dc.contributor.authorSkurzok, Magdalena - 106557
dc.contributor.authorStolarz, Anna
dc.contributor.authorSzumlak, Tomasz
dc.contributor.authorTanty, Pooja - 473795
dc.contributor.authorTayefi Ardebili, Keyvan - 460041
dc.contributor.authorTiwari, Satyam - 506042
dc.contributor.authorWalczak, Rafal
dc.contributor.authorStępień, Ewa - 161583
dc.contributor.authorMoskal, Paweł - 100401
dc.date.accessioned2025-10-21T14:28:14Z
dc.date.available2025-10-21T14:28:14Z
dc.date.createdat2025-10-16T07:39:21Zen
dc.date.issued2025
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalOnline First 2025-10-14
dc.description.physical1-11
dc.description.versionostateczna wersja wydawcy
dc.identifier.doi10.1109/TRPMS.2025.3621554
dc.identifier.eissn2469-7303
dc.identifier.issn2469-7311
dc.identifier.urihttps://ruj.uj.edu.pl/handle/item/563369
dc.languageeng
dc.language.containereng
dc.rightsDodaję tylko opis bibliograficzny
dc.rights.licenceCC-BY
dc.share.typeinne
dc.subject.enPositronium Lifetime Imaging
dc.subject.enPET
dc.subject.enNEMA
dc.subject.en44Sc
dc.subject.enJ-PET
dc.subject.enmedical imaging
dc.subject.enpositronium imaging
dc.subtypeArticle
dc.titleFirst positronium imaging using $^{44}$Sc with the J-PET scanner : a case study on the NEMA-Image Quality phantom
dc.title.journalIEEE Transactions on Radiation and Plasma Medical Sciences
dc.typeJournalArticle
dspace.entity.typePublicationen
dc.abstract.en
Positronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the positronium atom. Currently, the method is under rapid development in terms of reconstruction and detection systems. Recently, the first in vivo PLI of the human brain was performed using the J-PET scanner utilizing the 68Ga isotope. However, this isotope has limitations due to its comparatively low prompt gamma yields, which is crucial for positronium lifetime measurement. Among alternative radionuclides, 44Sc stands out as a promising isotope for PLI, characterized by a clinically suitable half-life (4.04 hours) emitting 1157 keV prompt gamma in 100% cases after the emission of the positron. This study reports the first experimental demonstration of PLI with 44Sc, carried out on a NEMA-Image Quality (IQ) phantom using the Modular J-PET tomograph–the first plastic scintillators-based PET scanner.
dc.affiliation
Szkoła Doktorska Nauk Ścisłych i Przyrodniczych
dc.affiliation
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
dc.affiliation
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Informatyki Stosowanej
dc.contributor.author
Das, Manish - 478556
dc.contributor.author
Sharma, Sushil - 200161
dc.contributor.author
Beyene, Ermias Yitayew - 473796
dc.contributor.author
Bilewicz, Aleksander
dc.contributor.author
Choinski, Jaroslaw
dc.contributor.author
Chug, Neha - 417025
dc.contributor.author
Curceanu, Catalina
dc.contributor.author
Czerwiński, Eryk - 102850
dc.contributor.author
Valsan Eliyan, Kavya - 460040
dc.contributor.author
Hajduga, Jakub
dc.contributor.author
Jalali, Sharareh - 507854
dc.contributor.author
Kacprzak, Krzysztof - 116744
dc.contributor.author
Kaplanoglu, Muhammed Tevfik - 477032
dc.contributor.author
Kapłon, Łukasz - 115081
dc.contributor.author
Kasperska, Kamila - 491314
dc.contributor.author
Khreptak, Aleksander - 262561
dc.contributor.author
Korcyl, Grzegorz - 107362
dc.contributor.author
Kozik, Tomasz - 129362
dc.contributor.author
Kubat, Karol - 228213
dc.contributor.author
Kumar, Deepak - 448421
dc.contributor.author
Kunimmal Venadan, Anoop - 497669
dc.contributor.author
Lisowski, Edward
dc.contributor.author
Lisowski, Filip
dc.contributor.author
Mędrala-Sowa, Justyna - 493140
dc.contributor.author
Moyo, Simbarashe - 459890
dc.contributor.author
Mryka, Wiktor - 385379
dc.contributor.author
Niedźwiecki, Szymon - 115136
dc.contributor.author
Pandey, Piyush - 497670
dc.contributor.author
Parzych, Szymon - 369531
dc.contributor.author
Porcelli, Alessio - 509000
dc.contributor.author
Rachwal, Bartlomiej
dc.contributor.author
Perez del Rio, Elena - 444273
dc.contributor.author
Rädler, Martin - 489637
dc.contributor.author
Rominger, Axel
dc.contributor.author
Shi, Kuangyu
dc.contributor.author
Skurzok, Magdalena - 106557
dc.contributor.author
Stolarz, Anna
dc.contributor.author
Szumlak, Tomasz
dc.contributor.author
Tanty, Pooja - 473795
dc.contributor.author
Tayefi Ardebili, Keyvan - 460041
dc.contributor.author
Tiwari, Satyam - 506042
dc.contributor.author
Walczak, Rafal
dc.contributor.author
Stępień, Ewa - 161583
dc.contributor.author
Moskal, Paweł - 100401
dc.date.accessioned
2025-10-21T14:28:14Z
dc.date.available
2025-10-21T14:28:14Z
dc.date.createdaten
2025-10-16T07:39:21Z
dc.date.issued
2025
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additional
Online First 2025-10-14
dc.description.physical
1-11
dc.description.version
ostateczna wersja wydawcy
dc.identifier.doi
10.1109/TRPMS.2025.3621554
dc.identifier.eissn
2469-7303
dc.identifier.issn
2469-7311
dc.identifier.uri
https://ruj.uj.edu.pl/handle/item/563369
dc.language
eng
dc.language.container
eng
dc.rights
Dodaję tylko opis bibliograficzny
dc.rights.licence
CC-BY
dc.share.type
inne
dc.subject.en
Positronium Lifetime Imaging
dc.subject.en
PET
dc.subject.en
NEMA
dc.subject.en
44Sc
dc.subject.en
J-PET
dc.subject.en
medical imaging
dc.subject.en
positronium imaging
dc.subtype
Article
dc.title
First positronium imaging using $^{44}$Sc with the J-PET scanner : a case study on the NEMA-Image Quality phantom
dc.title.journal
IEEE Transactions on Radiation and Plasma Medical Sciences
dc.type
JournalArticle
dspace.entity.typeen
Publication
Affiliations
Szkoła Doktorska Nauk Ścisłych i Przyrodniczych
Das, Manish
Beyene, Ermias Yitayew
Valsan Eliyan, Kavya
Jalali, Sharareh
Kaplanoglu, Muhammed Tevfik
Kasperska, Kamila
Kumar, Deepak
Mędrala-Sowa, Justyna
Moyo, Simbarashe
Mryka, Wiktor
Pandey, Piyush
Parzych, Szymon
Tanty, Pooja
Tayefi Ardebili, Keyvan
Tiwari, Satyam
Wydział Fizyki, Astronomii i Informatyki Stosowanej
Sharma, Sushil
Chug, Neha
Czerwiński, Eryk
Kacprzak, Krzysztof
Kapłon, Łukasz
Khreptak, Aleksander
Korcyl, Grzegorz
Kozik, Tomasz
Kubat, Karol
Kunimmal Venadan, Anoop
Niedźwiecki, Szymon
Porcelli, Alessio
Perez del Rio, Elena
Rädler, Martin
Skurzok, Magdalena
Stępień, Ewa
Moskal, Paweł
No affiliation
Bilewicz, Aleksander
Choinski, Jaroslaw
Curceanu, Catalina
Hajduga, Jakub
Lisowski, Edward
Lisowski, Filip
Rachwal, Bartlomiej
Rominger, Axel
Shi, Kuangyu
Stolarz, Anna
Szumlak, Tomasz
Walczak, Rafal

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