Cyklooksygenaza-2 i jej rola w kancerogenezie

2012
journal article
article
dc.abstract.enCyclooxygenase is an enzyme involved in many physiological and pathological processes. It catalyzes the formation of prostaglandins, prostacyclins and thromboxanes from arachidonic acid. It has been reported that cyclooxygenase-2 (COX-2) modulates the secretion of proinflammatory mediators and its expression is associated with the promotion of the process of tumorigenesis initiation, transformation, progression and cancer metastasis. Increased expression of COX-2 in premalignant lesions makes it a key element in a chain of changes leading to cancer. So far, advances in the evaluation of COX-2 molecular mechanisms did not bring spectacular discoveries. Pathomechanisms of COX-2 activities are still not sufficiently understood and therefore, require further research. Currently, COX-2 inhibitors are one of the most commonly used medications. Unfortunately, their long-term use causes many side effects. The first report about the use of plant substances with anti-inflammatory and analgesic activity (COX-2 inhibitors) was reported by Hippocrates in the 5th century BC. The present review discusses the most important mechanisms by which a particular COX-2 isomer leads to the formation and development of cancer.pl
dc.contributor.authorSitarz, Robertpl
dc.contributor.authorKolasińska-Bzoma, Małgorzatapl
dc.contributor.authorSkórzewska, Magdalenapl
dc.contributor.authorPolkowski, Wojciech P.pl
dc.contributor.authorMaciejewski, Ryszardpl
dc.date.accession2016-06-03pl
dc.date.accessioned2017-01-04T12:46:02Z
dc.date.available2017-01-04T12:46:02Z
dc.date.issued2012pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 34-39pl
dc.description.number5 (2)pl
dc.description.physical19-39pl
dc.description.versionostateczna wersja wydawcy
dc.identifier.eissn2082-3827pl
dc.identifier.issn2084-977Xpl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/34922
dc.identifier.weblinkftp://ftp.zpu.uj.edu.pl/towarzystwodoktorantow/zeszyty_naukowe/scisle/5_Zeszyty_Scisle_nr_5_ONLINE_2012.pdf#page=19pl
dc.languagepolpl
dc.language.containerpolpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 3.0 Polska*
dc.rights.licenceCC-BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/pl/legalcode*
dc.share.typeotwarte czasopismo
dc.subtypeArticlepl
dc.titleCyklooksygenaza-2 i jej rola w kancerogeneziepl
dc.title.journalZeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego. Nauki Ścisłepl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Cyclooxygenase is an enzyme involved in many physiological and pathological processes. It catalyzes the formation of prostaglandins, prostacyclins and thromboxanes from arachidonic acid. It has been reported that cyclooxygenase-2 (COX-2) modulates the secretion of proinflammatory mediators and its expression is associated with the promotion of the process of tumorigenesis initiation, transformation, progression and cancer metastasis. Increased expression of COX-2 in premalignant lesions makes it a key element in a chain of changes leading to cancer. So far, advances in the evaluation of COX-2 molecular mechanisms did not bring spectacular discoveries. Pathomechanisms of COX-2 activities are still not sufficiently understood and therefore, require further research. Currently, COX-2 inhibitors are one of the most commonly used medications. Unfortunately, their long-term use causes many side effects. The first report about the use of plant substances with anti-inflammatory and analgesic activity (COX-2 inhibitors) was reported by Hippocrates in the 5th century BC. The present review discusses the most important mechanisms by which a particular COX-2 isomer leads to the formation and development of cancer.
dc.contributor.authorpl
Sitarz, Robert
dc.contributor.authorpl
Kolasińska-Bzoma, Małgorzata
dc.contributor.authorpl
Skórzewska, Magdalena
dc.contributor.authorpl
Polkowski, Wojciech P.
dc.contributor.authorpl
Maciejewski, Ryszard
dc.date.accessionpl
2016-06-03
dc.date.accessioned
2017-01-04T12:46:02Z
dc.date.available
2017-01-04T12:46:02Z
dc.date.issuedpl
2012
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 34-39
dc.description.numberpl
5 (2)
dc.description.physicalpl
19-39
dc.description.version
ostateczna wersja wydawcy
dc.identifier.eissnpl
2082-3827
dc.identifier.issnpl
2084-977X
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/34922
dc.identifier.weblinkpl
ftp://ftp.zpu.uj.edu.pl/towarzystwodoktorantow/zeszyty_naukowe/scisle/5_Zeszyty_Scisle_nr_5_ONLINE_2012.pdf#page=19
dc.languagepl
pol
dc.language.containerpl
pol
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 3.0 Polska
dc.rights.licence
CC-BY-NC
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/3.0/pl/legalcode
dc.share.type
otwarte czasopismo
dc.subtypepl
Article
dc.titlepl
Cyklooksygenaza-2 i jej rola w kancerogenezie
dc.title.journalpl
Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego. Nauki Ścisłe
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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