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Cyklooksygenaza-2 i jej rola w kancerogenezie
Bibliogr. s. 34-39
Cyclooxygenase is an enzyme involved in many physiological and pathological processes. It catalyzes the formation of prostaglandins, prostacyclins and thromboxanes from arachidonic acid. It has been reported that cyclooxygenase-2 (COX-2) modulates the secretion of proinflammatory mediators and its expression is associated with the promotion of the process of tumorigenesis initiation, transformation, progression and cancer metastasis. Increased expression of COX-2 in premalignant lesions makes it a key element in a chain of changes leading to cancer. So far, advances in the evaluation of COX-2 molecular mechanisms did not bring spectacular discoveries. Pathomechanisms of COX-2 activities are still not sufficiently understood and therefore, require further research. Currently, COX-2 inhibitors are one of the most commonly used medications. Unfortunately, their long-term use causes many side effects. The first report about the use of plant substances with anti-inflammatory and analgesic activity (COX-2 inhibitors) was reported by Hippocrates in the 5th century BC. The present review discusses the most important mechanisms by which a particular COX-2 isomer leads to the formation and development of cancer.
dc.abstract.en | Cyclooxygenase is an enzyme involved in many physiological and pathological processes. It catalyzes the formation of prostaglandins, prostacyclins and thromboxanes from arachidonic acid. It has been reported that cyclooxygenase-2 (COX-2) modulates the secretion of proinflammatory mediators and its expression is associated with the promotion of the process of tumorigenesis initiation, transformation, progression and cancer metastasis. Increased expression of COX-2 in premalignant lesions makes it a key element in a chain of changes leading to cancer. So far, advances in the evaluation of COX-2 molecular mechanisms did not bring spectacular discoveries. Pathomechanisms of COX-2 activities are still not sufficiently understood and therefore, require further research. Currently, COX-2 inhibitors are one of the most commonly used medications. Unfortunately, their long-term use causes many side effects. The first report about the use of plant substances with anti-inflammatory and analgesic activity (COX-2 inhibitors) was reported by Hippocrates in the 5th century BC. The present review discusses the most important mechanisms by which a particular COX-2 isomer leads to the formation and development of cancer. | pl |
dc.contributor.author | Sitarz, Robert | pl |
dc.contributor.author | Kolasińska-Bzoma, Małgorzata | pl |
dc.contributor.author | Skórzewska, Magdalena | pl |
dc.contributor.author | Polkowski, Wojciech P. | pl |
dc.contributor.author | Maciejewski, Ryszard | pl |
dc.date.accession | 2016-06-03 | pl |
dc.date.accessioned | 2017-01-04T12:46:02Z | |
dc.date.available | 2017-01-04T12:46:02Z | |
dc.date.issued | 2012 | pl |
dc.date.openaccess | 0 | |
dc.description.accesstime | w momencie opublikowania | |
dc.description.additional | Bibliogr. s. 34-39 | pl |
dc.description.number | 5 (2) | pl |
dc.description.physical | 19-39 | pl |
dc.description.version | ostateczna wersja wydawcy | |
dc.identifier.eissn | 2082-3827 | pl |
dc.identifier.issn | 2084-977X | pl |
dc.identifier.uri | http://ruj.uj.edu.pl/xmlui/handle/item/34922 | |
dc.identifier.weblink | ftp://ftp.zpu.uj.edu.pl/towarzystwodoktorantow/zeszyty_naukowe/scisle/5_Zeszyty_Scisle_nr_5_ONLINE_2012.pdf#page=19 | pl |
dc.language | pol | pl |
dc.language.container | pol | pl |
dc.rights | Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 3.0 Polska | * |
dc.rights.licence | CC-BY-NC | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/pl/legalcode | * |
dc.share.type | otwarte czasopismo | |
dc.subtype | Article | pl |
dc.title | Cyklooksygenaza-2 i jej rola w kancerogenezie | pl |
dc.title.journal | Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego. Nauki Ścisłe | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |
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