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Applicability of attenuation imaging and shear wave elastography in non-invasive assessment of liver steatosis and fibrosis in adult patients
attenuation imaging
non-alcoholic fatty liver disease
shear wave elastography
ultrasonography
Bibliogr. s. e269-e270
Purpose: The study aims to assess whether: 1) shear wave elastography (2D-SWE) and attenuation imaging (ATI) can confirm or dispute ultrasonographic (USG) diagnosis of liver steatosis, 2) there is a correlation between 2D-SWE and ATI results, and 3) which blood tests and liver condition indices are most related to a higher F index among participants. Material and methods: A group of 117 participants (hepatitis B and hepatitis C negative) with B-mode USG-diagnosed fatty liver was examined using ATI and 2D-SWE. Blood tests were performed, and data were analysed for normality, model fitting, and the identification of predictors for a higher F index. The likelihood ratio test assessed variables and their odds ratio in relation to the fibrosis-4 index (FIB-4), followed by interaction analysis with reference patients. Results: ATI and 2D-SWE provided more accurate liver diagnostics than USG. F2-F3 stages correlated with older age, higher glucose, aspartate aminotransferase (AST), FIB-4, De Ritis, AST to platelet ratio index (APRI), and g-glutamyl transpeptidase (GGTP). The model showed that AST was a strong indicator of higher F index. Univariate analysis revealed that higher odds for F2-F3 stages were associated with elevated glucose, FIB-4, De Ritis, ATI, AST, and APRI. Compared to S0, values greater than S1 were linked to a higher F index. Interaction analysis showed that only FIB-4-GGTP was significant, with higher GGTP reducing the impact of FIB-4. Conclusions: ATI and 2D-SWE may complement USG in assessing liver condition. Key predictors for a higher F index include S index, AST, glucose, De Ritis, and FIB-4, with APRI being moderately relevant.
| dc.abstract.en | Purpose: The study aims to assess whether: 1) shear wave elastography (2D-SWE) and attenuation imaging (ATI) can confirm or dispute ultrasonographic (USG) diagnosis of liver steatosis, 2) there is a correlation between 2D-SWE and ATI results, and 3) which blood tests and liver condition indices are most related to a higher F index among participants. Material and methods: A group of 117 participants (hepatitis B and hepatitis C negative) with B-mode USG-diagnosed fatty liver was examined using ATI and 2D-SWE. Blood tests were performed, and data were analysed for normality, model fitting, and the identification of predictors for a higher F index. The likelihood ratio test assessed variables and their odds ratio in relation to the fibrosis-4 index (FIB-4), followed by interaction analysis with reference patients. Results: ATI and 2D-SWE provided more accurate liver diagnostics than USG. F2-F3 stages correlated with older age, higher glucose, aspartate aminotransferase (AST), FIB-4, De Ritis, AST to platelet ratio index (APRI), and g-glutamyl transpeptidase (GGTP). The model showed that AST was a strong indicator of higher F index. Univariate analysis revealed that higher odds for F2-F3 stages were associated with elevated glucose, FIB-4, De Ritis, ATI, AST, and APRI. Compared to S0, values greater than S1 were linked to a higher F index. Interaction analysis showed that only FIB-4-GGTP was significant, with higher GGTP reducing the impact of FIB-4. Conclusions: ATI and 2D-SWE may complement USG in assessing liver condition. Key predictors for a higher F index include S index, AST, glucose, De Ritis, and FIB-4, with APRI being moderately relevant. | |
| dc.contributor.author | Pozowski, Patryk | |
| dc.contributor.author | Bilski, Mateusz | |
| dc.contributor.author | Lewandowski, Łukasz | |
| dc.contributor.author | Zaleska-Dorobisz, Urszula | |
| dc.date.accessioned | 2026-08-17T07:05:19Z | |
| dc.date.available | 2026-08-17T07:05:19Z | |
| dc.date.createdat | 2026-08-17T07:05:19Z | en |
| dc.date.issued | 2026 | |
| dc.date.openaccess | 0 | |
| dc.description.accesstime | w momencie opublikowania | |
| dc.description.additional | Bibliogr. s. e269-e270 | |
| dc.description.number | 1 | |
| dc.description.physical | e255-e279 | |
| dc.description.version | ostateczna wersja wydawcy | |
| dc.description.volume | 91 | |
| dc.identifier.doi | 10.5114/pjr/215747 | |
| dc.identifier.issn | 1733-134X | |
| dc.identifier.project | DRC AI | |
| dc.identifier.uri | https://ruj.uj.edu.pl/handle/item/580831 | |
| dc.language | eng | |
| dc.language.container | eng | |
| dc.rights | Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa | |
| dc.rights.licence | CC-BY-NC-ND | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl | |
| dc.share.type | otwarte czasopismo | |
| dc.source.integrator | false | |
| dc.subject.en | attenuation imaging | |
| dc.subject.en | non-alcoholic fatty liver disease | |
| dc.subject.en | shear wave elastography | |
| dc.subject.en | ultrasonography | |
| dc.subtype | Article | |
| dc.title | Applicability of attenuation imaging and shear wave elastography in non-invasive assessment of liver steatosis and fibrosis in adult patients | |
| dc.title.journal | Polish Journal of Radiology | |
| dc.type | JournalArticle | |
| dspace.entity.type | Publication | en |
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