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Application of ultra-high dose rate (FLASH) proton beam for the 3D cancer cell model : a proof of concept

2023
journal article
article
10.5604/01.3001.0054.1820
Journal
Bio-Algorithms and Med-Systems
20
Author
Durak-Kozica Martyna

Stępień Ewa

Swakoń Jan

Moskal Paweł
Volume
19
Number
1
Pages
31-34
ISSN
1895-9091
eISSN
1896-530X
Keywords in English

FLASH proton radiotherapy

spheroids

melanoma cancer

extracellular vesicles

Language
English
Journal language
English
Abstract in English

Ultra-high dose rate (FLASH) proton radiotherapy is a promising treatment method for cancer patients. In our research, we want to compare the FLASH method with a conventional radiation method to show what effect they have on the biochemical structure of the tumour (3D model - spheroids) and the secretion of EVs and their cargo. The use of a modern method of creating spheroids will enable us to create conditions that are more able to mimic the tumour microenvironment.

Affiliation
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
cris.lastimport.wos2024-04-09T20:20:13Z
dc.abstract.enUltra-high dose rate (FLASH) proton radiotherapy is a promising treatment method for cancer patients. In our research, we want to compare the FLASH method with a conventional radiation method to show what effect they have on the biochemical structure of the tumour (3D model - spheroids) and the secretion of EVs and their cargo. The use of a modern method of creating spheroids will enable us to create conditions that are more able to mimic the tumour microenvironment.pl
dc.affiliationWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiegopl
dc.contributor.authorDurak-Kozica, Martyna - 148761 pl
dc.contributor.authorStępień, Ewa - 161583 pl
dc.contributor.authorSwakoń, Janpl
dc.contributor.authorMoskal, Paweł - 100401 pl
dc.date.accessioned2024-01-30T08:28:58Z
dc.date.available2024-01-30T08:28:58Z
dc.date.issued2023pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number1pl
dc.description.physical31-34pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume19pl
dc.identifier.doi10.5604/01.3001.0054.1820pl
dc.identifier.eissn1896-530Xpl
dc.identifier.issn1895-9091pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/326430
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enFLASH proton radiotherapypl
dc.subject.enspheroidspl
dc.subject.enmelanoma cancerpl
dc.subject.enextracellular vesiclespl
dc.subtypeArticlepl
dc.titleApplication of ultra-high dose rate (FLASH) proton beam for the 3D cancer cell model : a proof of conceptpl
dc.title.journalBio-Algorithms and Med-Systemspl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T20:20:13Z
dc.abstract.enpl
Ultra-high dose rate (FLASH) proton radiotherapy is a promising treatment method for cancer patients. In our research, we want to compare the FLASH method with a conventional radiation method to show what effect they have on the biochemical structure of the tumour (3D model - spheroids) and the secretion of EVs and their cargo. The use of a modern method of creating spheroids will enable us to create conditions that are more able to mimic the tumour microenvironment.
dc.affiliationpl
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
dc.contributor.authorpl
Durak-Kozica, Martyna - 148761
dc.contributor.authorpl
Stępień, Ewa - 161583
dc.contributor.authorpl
Swakoń, Jan
dc.contributor.authorpl
Moskal, Paweł - 100401
dc.date.accessioned
2024-01-30T08:28:58Z
dc.date.available
2024-01-30T08:28:58Z
dc.date.issuedpl
2023
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
1
dc.description.physicalpl
31-34
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
19
dc.identifier.doipl
10.5604/01.3001.0054.1820
dc.identifier.eissnpl
1896-530X
dc.identifier.issnpl
1895-9091
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/326430
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
FLASH proton radiotherapy
dc.subject.enpl
spheroids
dc.subject.enpl
melanoma cancer
dc.subject.enpl
extracellular vesicles
dc.subtypepl
Article
dc.titlepl
Application of ultra-high dose rate (FLASH) proton beam for the 3D cancer cell model : a proof of concept
dc.title.journalpl
Bio-Algorithms and Med-Systems
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations
Wydział Fizyki, Astronomii i Informatyki Stosowanej
Durak-Kozica, Martyna
Stępień, Ewa
Moskal, Paweł
No affiliation
Swakoń, Jan

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Except as otherwise noted, this item is licensed under : Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa

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