Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis : a Longitudinal Study of the International Pediatric Peritoneal Dialysis Network

2019
journal article
article
34
cris.lastimport.wos2024-04-09T21:10:55Z
dc.abstract.enWhile children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. The overall prevalence of underweight, and overweight/obesity at start of CPD was 8.9% and 19.7%, respectively. Underweight was most prevalent in South and Southeast Asia (20%), Central Europe (16.7%) and Turkey (15.2%), whereas overweight and obesity were most common in the Middle East (40%) and the US (33%). BMI SDS at PD initiation was associated positively with current eGFR and gastrostomy feeding prior to PD start. Over the course of PD BMI SDS tended to increase on CPD in underweight and normal weight children, whereas it decreased in initially overweight patients. In infancy, mortality risk was amplified by obesity, whereas in older children mortality was markedly increased in association with underweight. Both underweight and overweight are prevalent in pediatric ESKD, with the prevalence varying across the globe. Late dialysis start is associated with underweight, while enteral feeding can lead to obesity. Nutritional abnormalities tend to attenuate with time on dialysis. Mortality risk appears increased with obesity in infants and with underweight in older children.pl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.cm.date2020-01-07
dc.cm.id94446
dc.contributor.authorSchaefer, Franzpl
dc.contributor.authorBenner, Laurapl
dc.contributor.authorBorzych-Dużałka, Dagmarapl
dc.contributor.authorZaritsky, Joshuapl
dc.contributor.authorXu, Hongpl
dc.contributor.authorDrożdż, Dorota - 129246 pl
dc.contributor.authorRees, Lesleypl
dc.contributor.authorAntonio, Zenaida L.pl
dc.contributor.authorSerdaroglu, Erkinpl
dc.contributor.authorHooman, Nakysapl
dc.contributor.authorPatel, Hirenpl
dc.contributor.authorSever, Lalepl
dc.contributor.authorVondrak, Karelpl
dc.contributor.authorFlynn, Josephpl
dc.contributor.authorRébori, Anabellapl
dc.contributor.authorWong, Williampl
dc.contributor.authorHölttä, Tuulapl
dc.contributor.authorYildirim, Zeynep Yurukpl
dc.contributor.authorRanchin, Brunopl
dc.contributor.authorGrenda, Ryszardpl
dc.contributor.authorTesta, Sarapl
dc.contributor.authorSzabo, Attila J.pl
dc.contributor.authorEid, Loaipl
dc.contributor.authorBasu, Biswanathpl
dc.contributor.authorVitkevic, Renatapl
dc.contributor.authorWong, Cynthiapl
dc.contributor.authorPottoore, Stephen J.pl
dc.contributor.authorMüller, Dominikpl
dc.contributor.authorDusunsel, Ruhanpl
dc.contributor.authorGonzalez Celedon, Claudiapl
dc.contributor.authorFila, Marcpl
dc.contributor.authorSartz, Lisapl
dc.contributor.authorSander, Anjapl
dc.contributor.authorWarady, Bradley A.pl
dc.date.accessioned2020-01-17T10:09:12Z
dc.date.available2020-01-17T10:09:12Z
dc.date.issued2019pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.points140pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume9pl
dc.identifier.articleid4886pl
dc.identifier.doi10.1038/s41598-018-36975-zpl
dc.identifier.eissn2045-2322
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/146267
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subtypeArticlepl
dc.titleGlobal Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis : a Longitudinal Study of the International Pediatric Peritoneal Dialysis Networkpl
dc.title.journalScientific Reportspl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T21:10:55Z
dc.abstract.enpl
While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. The overall prevalence of underweight, and overweight/obesity at start of CPD was 8.9% and 19.7%, respectively. Underweight was most prevalent in South and Southeast Asia (20%), Central Europe (16.7%) and Turkey (15.2%), whereas overweight and obesity were most common in the Middle East (40%) and the US (33%). BMI SDS at PD initiation was associated positively with current eGFR and gastrostomy feeding prior to PD start. Over the course of PD BMI SDS tended to increase on CPD in underweight and normal weight children, whereas it decreased in initially overweight patients. In infancy, mortality risk was amplified by obesity, whereas in older children mortality was markedly increased in association with underweight. Both underweight and overweight are prevalent in pediatric ESKD, with the prevalence varying across the globe. Late dialysis start is associated with underweight, while enteral feeding can lead to obesity. Nutritional abnormalities tend to attenuate with time on dialysis. Mortality risk appears increased with obesity in infants and with underweight in older children.
dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii
dc.cm.date
2020-01-07
dc.cm.id
94446
dc.contributor.authorpl
Schaefer, Franz
dc.contributor.authorpl
Benner, Laura
dc.contributor.authorpl
Borzych-Dużałka, Dagmara
dc.contributor.authorpl
Zaritsky, Joshua
dc.contributor.authorpl
Xu, Hong
dc.contributor.authorpl
Drożdż, Dorota - 129246
dc.contributor.authorpl
Rees, Lesley
dc.contributor.authorpl
Antonio, Zenaida L.
dc.contributor.authorpl
Serdaroglu, Erkin
dc.contributor.authorpl
Hooman, Nakysa
dc.contributor.authorpl
Patel, Hiren
dc.contributor.authorpl
Sever, Lale
dc.contributor.authorpl
Vondrak, Karel
dc.contributor.authorpl
Flynn, Joseph
dc.contributor.authorpl
Rébori, Anabella
dc.contributor.authorpl
Wong, William
dc.contributor.authorpl
Hölttä, Tuula
dc.contributor.authorpl
Yildirim, Zeynep Yuruk
dc.contributor.authorpl
Ranchin, Bruno
dc.contributor.authorpl
Grenda, Ryszard
dc.contributor.authorpl
Testa, Sara
dc.contributor.authorpl
Szabo, Attila J.
dc.contributor.authorpl
Eid, Loai
dc.contributor.authorpl
Basu, Biswanath
dc.contributor.authorpl
Vitkevic, Renata
dc.contributor.authorpl
Wong, Cynthia
dc.contributor.authorpl
Pottoore, Stephen J.
dc.contributor.authorpl
Müller, Dominik
dc.contributor.authorpl
Dusunsel, Ruhan
dc.contributor.authorpl
Gonzalez Celedon, Claudia
dc.contributor.authorpl
Fila, Marc
dc.contributor.authorpl
Sartz, Lisa
dc.contributor.authorpl
Sander, Anja
dc.contributor.authorpl
Warady, Bradley A.
dc.date.accessioned
2020-01-17T10:09:12Z
dc.date.available
2020-01-17T10:09:12Z
dc.date.issuedpl
2019
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.pointspl
140
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
9
dc.identifier.articleidpl
4886
dc.identifier.doipl
10.1038/s41598-018-36975-z
dc.identifier.eissn
2045-2322
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/146267
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subtypepl
Article
dc.titlepl
Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis : a Longitudinal Study of the International Pediatric Peritoneal Dialysis Network
dc.title.journalpl
Scientific Reports
dc.typepl
JournalArticle
dspace.entity.type
Publication
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