Introduction and objective: Vaccinations as one of the highest achievements of medicine contributed to a significant reduction of infectious diseases. According to the current vaccination calendar in Poland, parent have possibility to choose free cost classic (DTP, polio, HBV) and not refundable 5- or 6-component combination vaccine. The aim of the study was to assess the popularity of the 5- and 6-component combination vaccines in years 2010-2019 among infants' parents starting a mandatory vaccination series in a selected Primary Health Care Clinic. Material and methods: The study was conducted at Med-All Medical Centre in Krakow which provided Protective Vaccination Program and included 1108 immunization cards of children born between 2010-2019. Most of the sample (98.5%) lived in Cracow. This retrospective ecological study was used analysis of medical records. Data analysis MS Excel (Microsoft) and PQStat Soft. The significance level was p< 0.05. Results: From 2010 to 2016, 5-component combination vaccine was the most popular choice for infants. During the study period the 5-component combination vaccine usage decrease with years (p=0.017). From 2017, the most popular was the 6-component vaccine and the usage increase with years with strong statistically significance (p=0.005). In 2019 there was the largest percentage of unvaccinated infants. Conclusions: Despite the costs, in 2010-2016, the most popular vaccine for infants was the 5-component high-combination vaccine. Since 2017, the 6-component vaccine has gained the greatest popularity.