In vivo biocompatibility assessment of (PTFE-PVDF-PP) terpolymer-based membrane with potential application for glaucoma treatment

2010
journal article
article
17
cris.lastimport.wos2024-04-09T19:26:56Z
dc.abstract.enThe aim of the work was to evaluate the in vivo biological behaviour of polymeric membrane materials for glaucoma implants. The base material was biostable synthetic terpolymer (PTFE-PVDF-PP) with proved biocompability (PN-EN ISO 10993). The samples manufactured in the form a membrane were subjected to chemical and physical treatment to create an open pore system within the polymer matrix. As a porogenic phase biodegradable natrium alginate in a fibrous form was employed. The non-perforating deep sclerectomy technique was performed in a rabbit model. The clinical observations were made after 14 and 30 days. During the study clinical symptoms of a moderate degree were observed, and histopathological changes were typical for foreign body implantation. At the end stage of the study no significant difference in histopathological assessment was found between control and experimental group. Similarities observed in both groups and relatively mild histopathological changes in the tissue surrounding the implant indicate that the observed symptoms come from a deep scleral trauma caused by surgery, and not by the presence of the implant itself.pl
dc.affiliationWydział Lekarski : Zakład Patomorfologii Klinicznej i Doświadczalnejpl
dc.contributor.authorLeszczynski, Rafałpl
dc.contributor.authorStodolak, Ewapl
dc.contributor.authorWieczorek, Jarosławpl
dc.contributor.authorOrłowska-Heitzman, Jolanta - 133045 pl
dc.contributor.authorGumula, Teresapl
dc.contributor.authorBlazewicz, Stanislawpl
dc.date.accession2020-05-22pl
dc.date.accessioned2020-05-22T06:40:30Z
dc.date.available2020-05-22T06:40:30Z
dc.date.issued2010pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 2850-2851pl
dc.description.number10pl
dc.description.physical2843-2851pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume21pl
dc.identifier.doi10.1007/s10856-010-4132-3pl
dc.identifier.eissn1573-4838pl
dc.identifier.issn0957-4530pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/156379
dc.identifier.weblinkhttps://link.springer.com/article/10.1007/s10856-010-4132-3pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne*
dc.rights.licenceCC-BY-NC
dc.rights.urihttps://creativecommons.org/licenses*
dc.share.typeinne
dc.subtypeArticlepl
dc.titleIn vivo biocompatibility assessment of (PTFE-PVDF-PP) terpolymer-based membrane with potential application for glaucoma treatmentpl
dc.title.journalJournal of Materials Science. Materials in Medicinepl
dc.typeJournalArticlepl
dspace.entity.typePublication
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