Repozytorium Uniwersytetu Jagiellońskiego
Raman microspectroscopy of human aortic valves : investigation of the local and global biochemical changes associated with calcification in aortic stenosis
Raman microspectroscopy of human aortic valves : ...
Opis pozycji
| tytuł: | Raman microspectroscopy of human aortic valves : investigation of the local and global biochemical changes associated with calcification in aortic stenosis |
| autor: | Czamara Krzysztof  , Natorska Joanna , Kapusta Przemysław, Barańska Małgorzata , Kaczor Agnieszka
|
| tytuł czasopisma: | Analyst |
| tom: | 140 |
| numer: | 7 |
| data wydania: | 2015 |
| strony: | 2164-2170 |
| ISSN: |
0003-2654 |
| eISSN: |
1364-5528 |
| DOI: | |
| język: | angielski |
| język czasopisma: | angielski |
| abstrakt w j. angielskim: | Raman microimaging was applied to study the biochemical composition in the aortic valves obtained from patients with calci fi c aortic stenosis. This progressive disease a ff ects an increasing number of elderly patients with hyperlipidemia and hypercholesterolemia. Lipid accumulation in the tissue is associated with pathogenesis and progression of cardiac valve calci fi cation. This is in line with our fi nding that lipid depo- sits, predominantly composed of cholesterol and its esters, are frequently co-localized with calcium salt deposits, even at an early stage of their development. Overall changes in the biochemical composition of the tissue upon pathology progression are less obvious. Globally, although the cholesterol level rises, the relative lipid-to-protein content decreases. The results broaden the knowledge of biochemical alterations in dysfunctional human aortic valves and may be helpful in designing lipid lowering therapies. |
| wydział:instytut/zakład/katedra: | Wydział Chemii : Zakład Fizyki Chemicznej, Wydział Lekarski : Instytut Kardiologii |
| typ: | artykuł w czasopiśmie |
| podtyp: | artykuł |
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