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Raman microspectroscopy of human aortic valves : investigation of the local and global biochemical changes associated with calcification in aortic stenosis
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Raman microspectroscopy of human aortic valves : investigation of the local and global biochemical changes associated with calcification in aortic stenosis
Bibliographic description
| title: | Raman microspectroscopy of human aortic valves : investigation of the local and global biochemical changes associated with calcification in aortic stenosis |
| author: | Czamara Krzysztof  , Natorska Joanna , Kapusta Przemysław, Barańska Małgorzata , Kaczor Agnieszka
|
| journal title: | Analyst |
| volume: | 140 |
| issue: | 7 |
| date of publication : | 2015 |
| pages: | 2164-2170 |
| ISSN: |
0003-2654 |
| eISSN: |
1364-5528 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | Raman microimaging was applied to study the biochemical composition in the aortic valves obtained from patients with calci fi c aortic stenosis. This progressive disease a ff ects an increasing number of elderly patients with hyperlipidemia and hypercholesterolemia. Lipid accumulation in the tissue is associated with pathogenesis and progression of cardiac valve calci fi cation. This is in line with our fi nding that lipid depo- sits, predominantly composed of cholesterol and its esters, are frequently co-localized with calcium salt deposits, even at an early stage of their development. Overall changes in the biochemical composition of the tissue upon pathology progression are less obvious. Globally, although the cholesterol level rises, the relative lipid-to-protein content decreases. The results broaden the knowledge of biochemical alterations in dysfunctional human aortic valves and may be helpful in designing lipid lowering therapies. |
| affiliation: | Wydział Chemii : Zakład Fizyki Chemicznej, Wydział Lekarski : Instytut Kardiologii |
| type: | journal article |
| subtype: | academic paper |
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Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
