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Design and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffold

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Design and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffold

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dc.contributor.author Szafrański, Przemysław [SAP20013999] pl
dc.contributor.author Dyduch, Karol [USOS36291] pl
dc.contributor.author Kościółek, Tomasz pl
dc.contributor.author Wróbel, Tomasz P. [USOS36247] pl
dc.contributor.author Gomez-Canas, Maria pl
dc.contributor.author Fernandez-Ruiz, Javier pl
dc.contributor.author Młynarski, Jacek [SAP11019877] pl
dc.contributor.author Gomes-Ruiz, Maria pl
dc.date.accessioned 2015-06-19T10:58:18Z
dc.date.available 2015-06-19T10:58:18Z
dc.date.issued 2013 pl
dc.identifier.issn 1570-1808 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/9916
dc.language eng pl
dc.title Design and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffold pl
dc.type JournalArticle pl
dc.description.physical 169-172 pl
dc.abstract.en Following "click chemistry" guidelines, a 1,2,3-triazole scaffold was introduced in place of a benzene ring to mimic the non-classical cannabinoid pharmacophore model in a novel class of compounds aimed at CB1 receptor agonism. The design, synthesis and results of receptor affinity tests for the new group of ligands are described. The obtained series exhibited a similar sidechainlength-activity relationship as in the initial pharmacophore model, with moderate CB1- selectivity. pl
dc.description.volume 10 pl
dc.description.number 2 pl
dc.description.points 15 pl
dc.identifier.doi 10.2174/157018013804725134 pl
dc.identifier.eissn 1875-628X pl
dc.title.journal Letters in Drug Design & Discovery pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Chemii Organicznej pl
dc.subtype Article pl
dc.rights.original bez licencji pl
dc.cm.id 61931
.pointsMNiSW [2013 A]: 15


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