Design and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffold

Bibliographic description

punktacja MNiSW [2013 A]: 15

title:	Design and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffold
author:	Szafrański Przemysław , Dyduch Karol , Kościółek Tomasz, Wróbel Tomasz P. , Gomez-Canas Maria, Fernandez-Ruiz Javier, Młynarski Jacek , Gomes-Ruiz Maria
journal title:	Letters in Drug Design & Discovery
volume:	10
issue:	2
date of publication :	2013
pages:	169-172
ISSN:	1570-1808
eISSN:	1875-628X
DOI:	10.2174/157018013804725134
language:	English
journal language:	English
abstract in English:	Following "click chemistry" guidelines, a 1,2,3-triazole scaffold was introduced in place of a benzene ring to mimic the non-classical cannabinoid pharmacophore model in a novel class of compounds aimed at CB1 receptor agonism. The design, synthesis and results of receptor affinity tests for the new group of ligands are described. The obtained series exhibited a similar sidechainlength-activity relationship as in the initial pharmacophore model, with moderate CB1- selectivity.
departmental parameterization:	15
affiliation:	Wydział Chemii : Zakład Chemii Organicznej
type:	journal article
subtype:	academic paper