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Design and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffold
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Design and synthesis of novel cannabinoid ligands ...
Bibliographic description
| title: | Design and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffold |
| author: | Szafrański Przemysław  , Dyduch Karol , Kościółek Tomasz, Wróbel Tomasz P. , Gomez-Canas Maria, Fernandez-Ruiz Javier, Młynarski Jacek , Gomes-Ruiz Maria |
| Journal title: | Letters in Drug Design & Discovery |
| volume: | 10 |
| issue: | 2 |
| date of publication: | 2013 |
| pages: | 169-172 |
| ISSN: |
1570-1808 |
| eISSN: |
1875-628X |
| DOI: | |
| language: | English |
| Journal language: | English |
| abstract in english: | Following "click chemistry" guidelines, a 1,2,3-triazole scaffold was introduced in place of a benzene ring to mimic the non-classical cannabinoid pharmacophore model in a novel class of compounds aimed at CB1 receptor agonism. The design, synthesis and results of receptor affinity tests for the new group of ligands are described. The obtained series exhibited a similar sidechainlength-activity relationship as in the initial pharmacophore model, with moderate CB1- selectivity. |
| affiliation: | Wydział Chemii : Zakład Chemii Organicznej |
| type: | journal article |
| subtype: | academic paper |
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