Multirate delivery of multiple therapeutic agents from metal-organic frameworks

Bibliographic description

title:	Multirate delivery of multiple therapeutic agents from metal-organic frameworks
author:	McKinlay Alistair C., Allan Phoebe K., Renouf Catherine L., Duncan Morven J., Wheatley Paul S., Warrender Steward J., Dawson Daniel, Ashbrook Sharon E., Gil Barbara , Marszałek Bartosz , Düren Tina, Williams Jenifer J., Charrier Cedric, Mercer Derry K., Teat Simon J., Morris Russell E.
journal title:	APL Materials
volume:	2
issue:	12
date of publication :	2014
article ID:	124108
eISSN:	2166-532X
DOI:	10.1063/1.4903290
URL:	https://aip.scitation.org/doi/pdf/10.1063/1.4903290?class=pdf
date accessed:	2019-02-14
language:	English
journal language:	English
abstract in other languages:	The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.
number of pulisher's sheets:	0,9
affiliation:	Wydział Chemii : Zakład Chemii Nieorganicznej
type:	journal article
subtype:	academic paper