title:
|
Effects of vanadium complexes supplementation on V, Cu, Mn, K, Fe, Zn, and Ca concentration in STZ diabetic rats pancreas |
author: |
Krośniak Mirosław , Kowalska Joanna, Francik Renata , Gryboś Ryszard , Kwiatek Wojciech M. |
journal title:
|
Acta Poloniae Pharmaceutica. Drug Research |
volume: |
71 |
issue:
|
4 |
date of publication
:
|
2014 |
pages:
|
583-592 |
ISSN: |
0001-6837
|
eISSN: |
2353-5288
|
URL: |
http://www.ptfarm.pl/pub/File/Acta_Poloniae/2014/4/583.pdf
|
date accessed: |
2016-05-27
|
language: |
English |
journal language:
|
English |
abstract in English: |
The objective of the study was to assess the effects of Na[V
V
O(O
2
)
2
(2,2í-bpy)] ◊ 8 H
2
O (complex 1),
Na[V
V
O(O
2
)
2
(1,10í-phen)] ◊ 5 H
2
O (complex 2
),
Na[V
V
O(O
2
)
2
(4,4í-Me-2,2í-bpy)] ◊ 8 H
2
O (complex 3
),
[
V
IV
O(SO
4
)(1,10í-phen)] ◊ 2 H
2
O, (complex 4
), [
V
IV
O(SO
4
)(2,2í-bpy)] ◊ H
2
O (complex 5
),
where: 2,2í-bpy =
2,2í-bipyridine, 1,10í-phen = 1,10í-phenanthroline, 4,4í-Me-2,2í-bpy = 4,4í-dimethyl-2,2í-bipyridine and a
small insulin injection on V, Cu, Mn, K, Fe, Zn, and Ca concentration in the STZ (streptozotocin) diabetic rats
pancreas during a 5-week treatment with the tested complexes. In all groups of animals metal concentration in
the pancreas was investigated by means of Proton Induced X-ray Emission (PIXE) method. Maximum con-
centration of vanadium was observed in the pancreas for complex 5 (1.69 ± 0.09 mg/kg dry weight), lower for
complex 3 (1.51 ± 0.10 mg/kg dry weight), and the lowest for complex 1 (1.21 ± 0.27 mg/kg dry weight) sup-
plementation. The influence of vanadium administration on other metalsí concentration in the ratsí pancreas
was also investigated. All vanadium-tested complexes showed an increase of zinc concentration in the exam-
ined pancreas in comparison to the diabetic animals not treated with vanadium. The results were the highest for
complex 1 and the lowest for complex 5. The concentration of Fe, Cu, Mn, K and Ca in the pancreas is not evi-
dently influenced by administration of the vanadium complexe. |
keywords in English: |
pancreas, potassium, calcium, manganese, zinc, copper, iron, vanadium, diabetes, rats, PIXE |
departmental parameterization: |
15 |
affiliation: |
Wydział Chemii : Zakład Chemii Nieorganicznej, Wydział Farmaceutyczny : Zakład Bromatologii, Wydział Farmaceutyczny : Zakład Chemii Bioorganicznej |
type: |
journal article |
subtype: |
academic paper |
punktacja MEiN [2014 A]: 15