Synteza i badania oddziaływania z albuminą N,N-dimetyloaminobenzylowej pochodnej tiosemikarbazonu i jej kompleksu z rutenem(II)

Synteza i badania oddziaływania z albuminą ...

punktacja MNiSW [2013 B]: 5

title:	Synteza i badania oddziaływania z albuminą N,N-dimetyloaminobenzylowej pochodnej tiosemikarbazonu i jej kompleksu z rutenem(II)
alternative title:	Synthesis and interaction with albumin of N,N-dimethylaminbenzyl derivative of thiosemicarbazone and its ruthenium(II) complex
author:	Łomzik Michał , Brindell Małgorzata
Journal title:	Chemik
volume:	67
issue:	2
date of publication:	2013
pages:	91-98
ISSN:	0009-2886
URL:	http://www.chemikinternational.com/year-2013/year-2013-issue-2/synthesis-and-interaction-with-albumin-of-nn-dimethylaminbenzyl-derivative-of-thiosemicarbazone-and-its-rutheniumii-complex-lomzik-m-brindell-m/
date accessed:	2015-05-27
notes:	Art. w 2 wersjach językowych: tekst w jęz. pol. (s. 91-94) i ang. (s. 95-98)
language:	Polish
Journal language:	Polish
abstract in english:	Previous studies have shown that some thiosemicarbazones have antitumor activity as inhibitors of ribonucleotide reductase and their reactivity can be enhanced by coordination to Ru ion. The following paper describes the synthesis of N,N-p-dimethylaminbenzaldehyde thiosemicarbazone and its Ru(II) complex. In addition, the interaction of the obtained compounds with albumin was carried out using fluorescence spectroscopy. It has been shown that coordination of ligand to ruthenium decrease its reactivity towards albumin and therefore the better bioavailability is expected.
affiliation:	Wydział Chemii : Zakład Chemii Nieorganicznej
type:	journal article
subtype:	academic paper