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Synteza i badania oddziaływania z albuminą N,N-dimetyloaminobenzylowej pochodnej tiosemikarbazonu i jej kompleksu z rutenem(II)
2013
journal article
article
Journal
Chemik
8
Alternative title
Synthesis and interaction with albumin of N,N-dimethylaminbenzyl derivative of thiosemicarbazone and its ruthenium(II) complex
Author
Łomzik Michał
Brindell Małgorzata
Volume
67
Issue
2
Pages
91-98
ISSN
0009-2886
URL
http://yadda.icm.edu.pl/baztech/element/bwmeta1.element.baztech-article-BPP2-0025-0094?q=bwmeta1.element.baztech-volume-0009-2886-chemik-2013-vol__67_nr_2;1&qt=CHILDREN-STATELESS
http://www.chemikinternational.com/year-2013/year-2013-issue-2/synthesis-and-interaction-with-albumin-of-nn-dimethylaminbenzyl-derivative-of-thiosemicarbazone-and-its-rutheniumii-complex-lomzik-m-brindell-m/
http://www.chemikinternational.com/year-2013/year-2013-issue-2/synthesis-and-interaction-with-albumin-of-nn-dimethylaminbenzyl-derivative-of-thiosemicarbazone-and-its-rutheniumii-complex-lomzik-m-brindell-m/
Access date
2019-06-11
Remarks
Art. w 2 wersjach językowych: tekst w jęz. pol. (s. 91-94) i ang. (s. 95-98)
Language
Polish
Container language
Polish
Abstract in English
Previous studies have shown that some thiosemicarbazones have antitumor activity as inhibitors of ribonucleotide reductase and their reactivity can be enhanced by coordination to Ru ion. The following paper describes the synthesis of N,N-p-dimethylaminbenzaldehyde thiosemicarbazone and its Ru(II) complex. In addition, the interaction of the obtained compounds with albumin was carried out using fluorescence spectroscopy. It has been shown that coordination of ligand to ruthenium decrease its reactivity towards albumin and therefore the better bioavailability is expected.
Affiliation
Wydział Chemii : Zakład Chemii Nieorganicznej
dc.abstract.en | Previous studies have shown that some thiosemicarbazones have antitumor activity as inhibitors of ribonucleotide reductase and their reactivity can be enhanced by coordination to Ru ion. The following paper describes the synthesis of N,N-p-dimethylaminbenzaldehyde thiosemicarbazone and its Ru(II) complex. In addition, the interaction of the obtained compounds with albumin was carried out using fluorescence spectroscopy. It has been shown that coordination of ligand to ruthenium decrease its reactivity towards albumin and therefore the better bioavailability is expected. | pl |
dc.affiliation | Wydział Chemii : Zakład Chemii Nieorganicznej | pl |
dc.contributor.author | Łomzik, Michał - 149678 | pl |
dc.contributor.author | Brindell, Małgorzata - 127426 | pl |
dc.date.accession | 2019-06-11 | pl |
dc.date.accessioned | 2015-06-17T06:43:20Z | |
dc.date.available | 2015-06-17T06:43:20Z | |
dc.date.issued | 2013 | pl |
dc.date.openaccess | 0 | |
dc.description.accesstime | w momencie opublikowania | |
dc.description.additional | Art. w 2 wersjach językowych: tekst w jęz. pol. (s. 91-94) i ang. (s. 95-98) | pl |
dc.description.number | 2 | pl |
dc.description.physical | 91-98 | pl |
dc.description.version | ostateczna wersja wydawcy | |
dc.description.volume | 67 | pl |
dc.identifier.issn | 0009-2886 | pl |
dc.identifier.uri | http://ruj.uj.edu.pl/xmlui/handle/item/9656 | |
dc.identifier.weblink | http://yadda.icm.edu.pl/baztech/element/bwmeta1.element.baztech-article-BPP2-0025-0094?q=bwmeta1.element.baztech-volume-0009-2886-chemik-2013-vol__67_nr_2;1&qt=CHILDREN-STATELESS | pl |
dc.identifier.weblink | http://www.chemikinternational.com/year-2013/year-2013-issue-2/synthesis-and-interaction-with-albumin-of-nn-dimethylaminbenzyl-derivative-of-thiosemicarbazone-and-its-rutheniumii-complex-lomzik-m-brindell-m/ | pl |
dc.language | pol | pl |
dc.language.container | pol | pl |
dc.rights.licence | OTHER | |
dc.share.type | inne | |
dc.subtype | Article | pl |
dc.title | Synteza i badania oddziaływania z albuminą N,N-dimetyloaminobenzylowej pochodnej tiosemikarbazonu i jej kompleksu z rutenem(II) | pl |
dc.title.alternative | Synthesis and interaction with albumin of N,N-dimethylaminbenzyl derivative of thiosemicarbazone and its ruthenium(II) complex | pl |
dc.title.journal | Chemik | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |