Repozytorium Uniwersytetu Jagiellońskiego

Antitumor lipids in biomembranes modeled with the Langmuir monolayer technique

Antitumor lipids in biomembranes modeled with the ...

Metadane (Dublin Core) Dynarowicz-Łątka, Patrycja [SAP11012997] pl 2015-06-11T10:05:46Z 2015-06-11T10:05:46Z 2014 pl
dc.identifier.issn 2050-6252 pl
dc.language eng pl
dc.title Antitumor lipids in biomembranes modeled with the Langmuir monolayer technique pl
dc.type JournalArticle pl
dc.description.physical 194-200 pl
dc.abstract.en Studies on interactions between physiologically active compounds and cell membrane components in Langmuir monolayers, which provide suitable models of biomembranes, can be considered as one of the crucial factors leading to the understanding of the mode of action of many drugs that act on membrane level. A good example of membrane-targeted drugs are synthetic analogues of lysophosphatidylcholine, generally named as antitumor lipids (ATLs), due to their anticancer properties. They have advantages over traditional cytostatics as they do not target DNA but cellular membrane. Apart from many studies on cell lines, little is known about the transport of ATLs to the cells, and it is still unclear which membrane components target drug molecules to the tumor cell membrane, sparing the normal cells. This review provides examples of the successful application of the Langmuir monolayer technique in getting insight into biological action and selectivity of representative ATL – edelfosine. pl
dc.subject.en interactions pl
dc.subject.en edelfosine pl
dc.subject.en thin film pl
dc.subject.en Langmuir monolayers pl
dc.subject.en biomimetic pl
dc.subject.en surface chemistry pl
dc.subject.en membrane models pl
dc.description.volume 2 pl
dc.description.number 3 pl
dc.description.publication 0,8 pl
dc.identifier.doi 10.1680/si.13.00030 pl
dc.identifier.eissn 2050-6260 pl
dc.title.journal Surface Innovations pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Chemii Ogólnej pl
dc.subtype Article pl
dc.rights.original bez licencji pl

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