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Asymmetric syn-aldol reaction of α-hydroxy ketones with tertiary amine catalysts

Asymmetric syn-aldol reaction of α-hydroxy ketones ...

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dc.contributor.author Baś, Sebastian [SAP14001996] pl
dc.contributor.author Woźniak, Łukasz pl
dc.contributor.author Cygan, Judyta pl
dc.contributor.author Młynarski, Jacek [SAP11019877] pl
dc.date.accessioned 2015-06-08T12:01:50Z
dc.date.available 2015-06-08T12:01:50Z
dc.date.issued 2013 pl
dc.identifier.issn 1434-193X pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/8985
dc.language eng pl
dc.title Asymmetric syn-aldol reaction of α-hydroxy ketones with tertiary amine catalysts pl
dc.type JournalArticle pl
dc.description.physical 6917-6923 pl
dc.abstract.en The tertiary amine-catalyzed direct asymmetric aldol reac- tion of 2-hydroxyacetophenones (2-hydroxy-1-arylethan- ones) with a variety of aliphatic aldehydes has been demon- strated. By using 20 mol-% of unmodified cinchonine as cata- lyst, the direct aldol reaction products were isolated in good yields and with remarkably high syn diastereocontrol andgood asymmetric induction (40–78% ee ). This newly elabo- rated tertiary-amine-catalyzed direct asymmetric aldol reac- tion has extended the scope of organocatalytic processes to aromatic α -hydroxy ketones, which have hitherto been unre- active towards enamine catalysis. pl
dc.description.volume 2013 pl
dc.description.number 30 pl
dc.identifier.doi 10.1002/ejoc.201300872 pl
dc.identifier.eissn 1099-0690 pl
dc.title.journal European Journal of Organic Chemistry pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Chemii Organicznej pl
dc.subtype Article pl
dc.rights.original bez licencji pl
.pointsMNiSW [2013 A]: 35


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