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Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway

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Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway

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dc.contributor.author Pochwat, Bartłomiej [SAP20011028] pl
dc.contributor.author Sowa-Kućma, Magdalena pl
dc.contributor.author Kotarska, Katarzyna [SAP12017458] pl
dc.contributor.author Misztak, Paulina pl
dc.contributor.author Nowak, Gabriel [SAP20001917] pl
dc.contributor.author Szewczyk, Bernadeta pl
dc.date.accessioned 2015-05-27T11:22:27Z
dc.date.available 2015-05-27T11:22:27Z
dc.date.issued 2015 pl
dc.identifier.issn 0033-3158 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/8241
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway pl
dc.type JournalArticle pl
dc.description.physical 355-367 pl
dc.abstract.en Rationale. Numerous studies suggest agents that act on glutamatergic transmission as potential antidepressants. Preclinical and clinical evidence suggests that magnesium, an N-methyl-d-aspartate receptor blocker, may be useful in the treatment of depression. Objective. The aim of this study was to investigate the effects of magnesium on behavior; protein levels of GluN2A, GluN2B [N-methyl-d-aspartate receptor (NMDAR) subunits], GluA1 [α-amino-3-hydroxy-5 methyl-4-isoxazolepropionic acid (AMPA) subunit], phospho-Ser-831-GluA1 (P-S831), phospho-Ser-845-GluA1 (P-S845), and brain-derived neurotrophic factor (BDNF); and messenger RNA (mRNA) levels of GluN2A and GluN2B in different brain areas in the olfactory bulbectomy (OB) model of depression in rats. Methods. Magnesium was administered once daily for 14 days at three doses (10, 15, and 20 mg/kg, intraperitoneal) to sham and OB rats. Following treatment, open field and passive avoidance tests were performed in the sham and OB rats. After 24 h, the hippocampus, the prefrontal cortex (PFC), and the amygdala of rats treated with the most active dose (15 mg/kg) were harvested, and the protein and mRNA levels were determined. Results. Chronic administration of magnesium (15 and 20 mg/kg) reduced the number of trials required to learn passive avoidance and reduced the OB-induced hyperactivity. OB increased the P-S845 level in the hippocampus, which was reduced by magnesium treatment. Magnesium significantly increased the levels of BDNF, GluN2B, P-S831, and P-S845 protein (and mRNA) primarily in the PFC and the hippocampus in OB rats. Conclusion. For the first time, the present results demonstrate the antidepressant-like activity of magnesium in the OB animal model of depression and indicate the potential involvement of the AMPA/BDNF pathway in this activity. pl
dc.subject.en olfactory bulbectomy pl
dc.subject.en magnesium pl
dc.subject.en NMDA pl
dc.subject.en AMPA pl
dc.subject.en BDNF pl
dc.subject.en glutamatergic system pl
dc.subject.en depression pl
dc.description.volume 232 pl
dc.description.number 2 pl
dc.description.points 35 pl
dc.identifier.doi 10.1007/s00213-014-3671-6 pl
dc.identifier.eissn 1432-2072 pl
dc.title.journal Psychopharmacology pl
dc.language.container eng pl
dc.affiliation Wydział Farmaceutyczny : Zakład Cytobiologii pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original CC-BY; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / P pl
dc.cm.id 67946
.pointsMNiSW [2015 A]: 35


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Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa