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Affinity of alkylphosphocholines to biological membrane of prostate cancer : studies in natural and model systems

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Affinity of alkylphosphocholines to biological membrane of prostate cancer : studies in natural and model systems

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dc.contributor.author Wnętrzak, Anita [SAP14013174] pl
dc.contributor.author Lipiec, Ewelina pl
dc.contributor.author Łątka, Kazimierz [SAP11007627] pl
dc.contributor.author Kwiatek, Wojciech pl
dc.contributor.author Dynarowicz-Łątka, Patrycja [SAP11012997] pl
dc.date.accessioned 2015-05-27T08:36:49Z
dc.date.available 2015-05-27T08:36:49Z
dc.date.issued 2014 pl
dc.identifier.issn 0022-2631 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/8181
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title Affinity of alkylphosphocholines to biological membrane of prostate cancer : studies in natural and model systems pl
dc.type JournalArticle pl
dc.description.physical 581-589 pl
dc.identifier.weblink https://link.springer.com/content/pdf/10.1007%2Fs00232-014-9674-8.pdf pl
dc.abstract.en The effectiveness of two alkylphosphocholines (APCs), hexadecylphosphocholine (miltefosine) and erucylphosphocholine to combat prostate cancer has been studied in vitro with artificial cancerous membrane, modelled with the Langmuir monolayer technique, and on cell line (Du-145). Studies performed with the Langmuir method indicate that both the investigated drugs have the affinity to the monolayer mimicking prostate cancer membrane (composed of cholesterol:POPC = 0.428) and the drug-membrane interactions are stronger for erucylphosphocholine as compared to hexadecylphosphocholine. Moreover, both studied drugs were found to fluidize the model membrane, which may lead to apoptosis. Indeed, biological studies confirmed that in Du-145 cell line both investigated alkylphosphocholines cause cell death primarily by apoptosis while necrotic cells constitute only a small percentage of APC-treated cells. pl
dc.subject.en alkylphosphocholines pl
dc.subject.en model membrane pl
dc.subject.en Langmuir monolayers pl
dc.subject.en prostate cancer pl
dc.description.volume 247 pl
dc.description.number 7 pl
dc.description.publication 0,5 pl
dc.identifier.doi 10.1007/s00232-014-9674-8 pl
dc.identifier.eissn 1432-1424 pl
dc.title.journal The Journal of Membrane Biology pl
dc.language.container eng pl
dc.date.accession 2019-03-11 pl
dc.affiliation Wydział Chemii : Zakład Chemii Ogólnej pl
dc.affiliation Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego pl
dc.subtype Article pl
dc.rights.original CC-BY; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / P pl
.pointsMNiSW [2014 A]: 20


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Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa