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Affinity of alkylphosphocholines to biological membrane of prostate cancer : studies in natural and model systems
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
Affinity of alkylphosphocholines to biological membrane of prostate cancer : studies in natural and model systems
Bibliographic description
| title: | Affinity of alkylphosphocholines to biological membrane of prostate cancer : studies in natural and model systems |
| author: | Wnętrzak Anita  , Lipiec Ewelina, Łątka Kazimierz , Kwiatek Wojciech, Dynarowicz-Łątka Patrycja
|
| journal title: | The Journal of Membrane Biology |
| volume: | 247 |
| issue: | 7 |
| date of publication : | 2014 |
| pages: | 581-589 |
| ISSN: |
0022-2631 |
| eISSN: |
1432-1424 |
| DOI: | |
| URL: |
https://link.springer.com/content/pdf/10.1007%2Fs00232-014-9674-8.pdf |
| date accessed: |
2019-03-11 |
| language: | English |
| journal language: | English |
| abstract in English: | The effectiveness of two alkylphosphocholines (APCs), hexadecylphosphocholine (miltefosine) and erucylphosphocholine to combat prostate cancer has been studied in vitro with artificial cancerous membrane, modelled with the Langmuir monolayer technique, and on cell line (Du-145). Studies performed with the Langmuir method indicate that both the investigated drugs have the affinity to the monolayer mimicking prostate cancer membrane (composed of cholesterol:POPC = 0.428) and the drug-membrane interactions are stronger for erucylphosphocholine as compared to hexadecylphosphocholine. Moreover, both studied drugs were found to fluidize the model membrane, which may lead to apoptosis. Indeed, biological studies confirmed that in Du-145 cell line both investigated alkylphosphocholines cause cell death primarily by apoptosis while necrotic cells constitute only a small percentage of APC-treated cells. |
| keywords in English: | alkylphosphocholines, model membrane, Langmuir monolayers, prostate cancer |
| number of pulisher's sheets: | 0,5 |
| affiliation: | Wydział Chemii : Zakład Chemii Ogólnej, Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
