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A novel in-vitro model of human aortic valve mineralization


A novel in-vitro model of human aortic valve mineralization

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dc.contributor.author Goncerz, Grzegorz [SAP20001140] pl
dc.contributor.author Tomaszewski, Krzysztof A. [SAP20014544] pl
dc.contributor.author Pasternak, Artur [SAP20002505] pl
dc.contributor.author Głowacki, Roman pl
dc.contributor.author Wróbel, Andrzej [SAP12011413] pl
dc.contributor.author Rokita, Eugeniusz [SAP11009973] pl
dc.contributor.author Podolec, Piotr [SAP20000862] pl
dc.date.accessioned 2015-05-26T14:00:31Z
dc.date.available 2015-05-26T14:00:31Z
dc.date.issued 2014 pl
dc.identifier.issn 0966-8519 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/8153
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title A novel in-vitro model of human aortic valve mineralization pl
dc.type JournalArticle pl
dc.description.physical 545-549 pl
dc.abstract.en Background and aim of the study: The study aim was to develop an in-vitro model of human aortic valve homograft (AVH) mineralization, as a basis for further research on the subject of calcific aortic valve disease (CAVD). Methods: Human aortic valves were excised during autopsy (12-24 h post-mortem) from donors who had died due to accident or suicide. The mean \left ( \pm SD \right ) donor age was \left ( 32.5\pm 11.4 \right ) years. Under sterile conditions each aortic cusp (three cusps per valve) was cut in half to provide a total of 240 tissue samples. AVH mineralization was assessed in solutions with different Ca and P concentrations and Ca x PO_{4} ionic product values. The impact of time on aortic valve mineralization rate was assessed using energy-dispersive X-ray fluorescence (ED-XRF). Results: The model showed that human AVH mineralization can be best observed in a solution with a Ca x PO_{4} ionic product of 2.2 mmol^{2}/l^{2}. The optimum incubation time for observing AVH mineralization was 21 days. Conclusion: A novel in-vitro AVH mineralization model was developed for use in future studies. pl
dc.description.volume 23 pl
dc.description.number 5 pl
dc.description.points 15 pl
dc.identifier.eissn 2053-2644 pl
dc.title.journal The Journal of Heart Valve Disease pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Instytut Kardiologii pl
dc.affiliation Wydział Lekarski : Zakład Anatomii pl
dc.affiliation Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego pl
dc.subtype Article pl
dc.rights.original bez licencji pl
dc.cm.id 68400
.pointsMNiSW [2014 A]: 15

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