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Novel polymeric inhibitors of HCoV-NL63

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Novel polymeric inhibitors of HCoV-NL63

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dc.contributor.author Milewska, Aleksandra [SAP14000316] pl
dc.contributor.author Ciejka, Justyna [USOS35617] pl
dc.contributor.author Kamiński, Kamil [SAP14003414] pl
dc.contributor.author Karewicz, Anna [SAP11116721] pl
dc.contributor.author Bielska, Dorota [USOS846] pl
dc.contributor.author Żegleń, Sławomir pl
dc.contributor.author Karolak, Wojciech pl
dc.contributor.author Nowakowska, Maria [SAP11005597] pl
dc.contributor.author Potempa, Jan [SAP11010833] pl
dc.contributor.author Bosch, Berend Jan pl
dc.contributor.author Pyrć, Krzysztof [SAP11019543] pl
dc.contributor.author Szczubiałka, Krzysztof [SAP11014318] pl
dc.date.accessioned 2015-05-20T07:22:30Z
dc.date.available 2015-05-20T07:22:30Z
dc.date.issued 2013 pl
dc.identifier.issn 0166-3542 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/7491
dc.language eng pl
dc.title Novel polymeric inhibitors of HCoV-NL63 pl
dc.type JournalArticle pl
dc.description.physical 112-121 pl
dc.abstract.en The human coronavirus NL63 is generally classified as a common cold pathogen, though the infection may also result in severe lower respiratory tract diseases, especially in children, patients with underlying disease, and elderly. It has been previously shown that HCoV-NL63 is also one of the most important causes of croup in children. In the current manuscript we developed a set of polymer-based compounds showing prominent anticoronaviral activity. Polymers have been recently considered as promising alter- natives to small molecule inhibitors, due to their intrinsic antimicrobial properties and ability to serve as matrices for antimicrobial compounds. Most of the antimicrobial polymers show antibacterial properties, while those with antiviral activity are much less frequent. A cationically modified chitosan derivative, N -(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and hydrophobically-modified HTCC were shown to be potent inhibitors of HCoV-NL63 replication. Furthermore, both compounds showed prominent activity against murine hepatitis virus, suggesting broader anticoronaviral activity. pl
dc.description.volume 97 pl
dc.description.number 2 pl
dc.identifier.doi 10.1016/j.antiviral.2012.11.006 pl
dc.identifier.eissn 1872-9096 pl
dc.title.journal Antiviral Research pl
dc.language.container eng pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Mikrobiologii pl
dc.affiliation Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii pl
dc.subtype Article pl
dc.rights.original bez licencji pl
.pointsMNiSW [2013 A]: 35


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