Novel polymeric inhibitors of HCoV-NL63

doi:10.1016/j.antiviral.2012.11.006

Novel polymeric inhibitors of HCoV-NL63

Bibliographic description

punktacja MNiSW [2013 A]: 35

title:	Novel polymeric inhibitors of HCoV-NL63
author:	Milewska Aleksandra , Ciejka Justyna , Kamiński Kamil , Karewicz Anna , Bielska Dorota , Żegleń Sławomir, Karolak Wojciech, Nowakowska Maria , Potempa Jan , Bosch Berend Jan, Pyrć Krzysztof , Szczubiałka Krzysztof
Journal title:	Antiviral Research
volume:	97
issue:	2
date of publication:	2013
pages:	112-121
ISSN:	0166-3542
eISSN:	1872-9096
DOI:	10.1016/j.antiviral.2012.11.006
language:	English
Journal language:	English
abstract in english:	The human coronavirus NL63 is generally classified as a common cold pathogen, though the infection may also result in severe lower respiratory tract diseases, especially in children, patients with underlying disease, and elderly. It has been previously shown that HCoV-NL63 is also one of the most important causes of croup in children. In the current manuscript we developed a set of polymer-based compounds showing prominent anticoronaviral activity. Polymers have been recently considered as promising alter- natives to small molecule inhibitors, due to their intrinsic antimicrobial properties and ability to serve as matrices for antimicrobial compounds. Most of the antimicrobial polymers show antibacterial properties, while those with antiviral activity are much less frequent. A cationically modified chitosan derivative, N -(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and hydrophobically-modified HTCC were shown to be potent inhibitors of HCoV-NL63 replication. Furthermore, both compounds showed prominent activity against murine hepatitis virus, suggesting broader anticoronaviral activity.
affiliation:	Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Mikrobiologii, Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii
type:	journal article
subtype:	academic paper