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Electrophysiology and pharmacology of the optic input to the rat intergeniculate leaflet in vitro


Electrophysiology and pharmacology of the optic input to the rat intergeniculate leaflet in vitro

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dc.contributor.author Błasiak, Anna [SAP11019675] pl
dc.contributor.author Błasiak, Tomasz [SAP11018153] pl
dc.contributor.author Lewandowski, Marian [SAP11009721] pl
dc.date.accessioned 2019-05-07T06:23:48Z
dc.date.available 2019-05-07T06:23:48Z
dc.date.issued 2009 pl
dc.identifier.issn 0867-5910 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/74138
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Electrophysiology and pharmacology of the optic input to the rat intergeniculate leaflet in vitro pl
dc.type JournalArticle pl
dc.description.physical 171-180 pl
dc.description.additional Bibliogr. s. 179-180 pl
dc.identifier.weblink http://www.jpp.krakow.pl/journal/archive/03_09/pdf/171_03_09_article.pdf pl
dc.abstract.en The mammalian intergeniculate leaflet (IGL) of the thalamus is a neuronal element of the circadian timing system, which receives direct photic input from the retina. The purpose of this study was to analyze responses of rat IGL neurons in vitro to optic tract stimulation and to identify neurotransmitters released from the terminals of retinal ganglion cells in this structure. Following optic tract stimulation, most of the responding IGL cells were excited and only a minority of them were inhibited. Neurons showing the excitatory response were tested in the presence of AP-5, a selective antagonist of NMDA receptors. In most cases the responses were only partially inhibited by the presence of AP-5. Complete disappearance of excitatory responses was achieved by adding CNQX, an AMPA/kainate receptor-selective antagonist, to the standard incubation fluid. Inhibitory responses were blocked or considerably attenuated in the presence of bicuculline, a GABA_{A} receptor antagonist, in the ACSF. This study demonstrated that glutamate is the main neurotransmitter mediating optic tract input to the IGL, acting mainly via non-NMDA ionotropic receptors. It was also shown that NMDA and GABA_{A} receptors are involved in passing photic input to the IGL, albeit to a much lesser extent. pl
dc.subject.en photic input pl
dc.subject.en glutamate pl
dc.subject.en circadian rhythms pl
dc.description.volume 60 pl
dc.description.number 1 pl
dc.identifier.eissn 1899-1505 pl
dc.title.journal Journal of Physiology and Pharmacology pl
dc.language.container eng pl
dc.date.accession 2019-04-26 pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original OTHER; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / O pl

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