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Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis : preliminary results

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Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis : preliminary results

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dc.contributor.author Marciniewicz, Ewelina pl
dc.contributor.author Pokryszko-Dragan, Anna pl
dc.contributor.author Podgórski, Przemysław pl
dc.contributor.author Małyszczak, Krzysztof pl
dc.contributor.author Zimny, Anna pl
dc.contributor.author Kołtowska, Anna pl
dc.contributor.author Budrewicz, Sławomir pl
dc.contributor.author Sąsiadek, Marek pl
dc.contributor.author Bladowska, Joanna pl
dc.date.accessioned 2019-04-25T10:42:56Z
dc.date.available 2019-04-25T10:42:56Z
dc.date.issued 2019 pl
dc.identifier.issn 1733-134X pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/73733
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/pl/legalcode *
dc.title Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis : preliminary results pl
dc.type JournalArticle pl
dc.description.physical e171-e178 pl
dc.description.additional Bibliogr. s. e177-e178 pl
dc.abstract.en Purpose: The aim of this volumetric study was to evaluate the relationship between brain atrophy quantification in multiple sclerosis (MS) patients and the progression of disability measured by neurological standardised tests. Material and methods: Seventeen patients (mean age 40.89 years) with clinically definite MS and 24 control subjects (mean age 38.45 years) were enrolled in the study. Brain examinations were performed on a 1.5T MR scanner. Automatic brain segmentation was done using FreeSurfer. Neurological disability was assessed in all patients in baseline and after a median follow-up of two years, using EDSS score evaluation. Results: In MS patients we found significantly (p < 0.05) higher atrophy rates in many brain areas compared with the control group. The white matter did not show any significant rate of volume loss in MS patients compared to healthy controls. Significant changes were found only in grey matter volume in MS subjects. At the follow-up evaluation after two years MS patients with deterioration in disability revealed significantly decreased cerebral volume in 14 grey matter areas at baseline magnetic resonance imaging (MRI) compared to MS subjects without disability progression. Conclusions: Grey matter atrophy is associated with the degree of disability in MS patients. Our results suggest that morphometric measurements of brain volume could be a promising non-invasive biomarker in assessing the volumetric changes in MS patients as related to disability progression in the course of the disease. pl
dc.subject.en multiple sclerosis pl
dc.subject.en magnetic resonance volumetry pl
dc.subject.en neurocognitive dysfunction pl
dc.subject.en EDSS pl
dc.subject.en brain atrophy pl
dc.description.volume 84 pl
dc.identifier.doi 10.5114/pjr.2019.84274 pl
dc.identifier.eissn 1899-0967 pl
dc.title.journal Polish Journal of Radiology pl
dc.language.container eng pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa