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Antidepressant-like effect of chromium chloride in the mouse forced swim test : involvement of glutamatergic and serotonergic receptors

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Antidepressant-like effect of chromium chloride in the mouse forced swim test : involvement of glutamatergic and serotonergic receptors

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dc.contributor.author Piotrowska, Anna [USOS49054] pl
dc.contributor.author Młyniec, Katarzyna [USOS96972] pl
dc.contributor.author Siwek, Agata [SAP20008614] pl
dc.contributor.author Dybała, Małgorzata pl
dc.contributor.author Opoka, Włodzimierz [SAP20000419] pl
dc.contributor.author Poleszak, Ewa pl
dc.contributor.author Nowak, Gabriel [SAP20001917] pl
dc.date.accessioned 2019-04-18T07:06:06Z
dc.date.available 2019-04-18T07:06:06Z
dc.date.issued 2008 pl
dc.identifier.issn 1734-1140 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/73413
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Antidepressant-like effect of chromium chloride in the mouse forced swim test : involvement of glutamatergic and serotonergic receptors pl
dc.type JournalArticle pl
dc.description.physical 991-995 pl
dc.identifier.weblink http://if-pan.krakow.pl/pjp/pdf/2008/6_991.pdf pl
dc.abstract.en Chromium (Cr) (III), an essential microelement of living organisms, was reported to exhibit potential antidepressant properties in preclinical and clinical studies. The aim of the present study was to examine the effect of CrCl(3) ip administration in the forced swim test (FST) in mice and the involvement of glutamatergic and serotonergic receptors in the antidepressant-like activity of chromium. CrCl(3) in a dose of 12 mg/kg, but not in doses of 6 or 32 mg/kg, reduced the immobility time in the FST. The locomotor activity was reduced by CrCl(3) in a dose of 32 mg/kg. Moreover, the reduction of the immobility time induced by the active dose (12 mg/kg) of CrCl(3) was completely abolished by NBQX (10 mg/kg; an antagonist of the AMPA receptor) pretreatment and partially inhibited by ritanserin (4 mg/kg; an antagonist of 5-HT(2A/C) receptor), WAY 1006335 (0.1 mg/kg; an antagonist of 5-HT(1A) receptor) and N-methyl-D-aspartate (75 mg/kg; agonist of NMDA receptor) administration. The present study demonstrates the antidepressant-like activity of chromium in the mouse FST and indicates the major role of the AMPA receptor and participation of NMDA glutamatergic and 5-HT(1) and 5-HT(2A/C) serotonin receptors in this activity. pl
dc.subject.en animals pl
dc.subject.en antidepressive agents pl
dc.subject.en chlorides pl
dc.subject.en chromium compounds pl
dc.subject.en depression pl
dc.subject.en drug therapy pl
dc.subject.en male pl
dc.subject.en mice pl
dc.subject.en quinoxalines pl
dc.subject.en AMPA pl
dc.subject.en N-methyl-D-aspartate pl
dc.subject.en serotonin pl
dc.subject.en receptors pl
dc.subject.en ritanserin pl
dc.subject.en swimming pl
dc.description.volume 60 pl
dc.description.number 6 pl
dc.identifier.eissn 2299-5684 pl
dc.title.journal Pharmacological Reports pl
dc.language.container eng pl
dc.date.accession 2020-08-10 pl
dc.affiliation Wydział Farmaceutyczny : Zakład Chemii Nieorganicznej pl
dc.affiliation Wydział Farmaceutyczny : Zakład Cytobiologii pl
dc.subtype Article pl
dc.rights.original OTHER; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / O pl


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