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Filamentous aggregates of tau proteins fulfil standard amyloid criteria provided by the fuzzy oil drop (FOD) model

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Filamentous aggregates of tau proteins fulfil standard amyloid criteria provided by the fuzzy oil drop (FOD) model

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dc.contributor.author Dułak, Dawid pl
dc.contributor.author Gadzała, Małgorzata pl
dc.contributor.author Banach, Mateusz [SAP20011078] pl
dc.contributor.author Ptak-Kaczor, Magdalena [SAP20018612] pl
dc.contributor.author Wiśniowski, Zdzisław [SAP20006268] pl
dc.contributor.author Konieczny, Leszek pl
dc.contributor.author Roterman-Konieczna, Irena [SAP20000474] pl
dc.date.accessioned 2019-03-20T12:24:32Z
dc.date.available 2019-03-20T12:24:32Z
dc.date.issued 2018 pl
dc.identifier.issn 1661-6596 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/70941
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title Filamentous aggregates of tau proteins fulfil standard amyloid criteria provided by the fuzzy oil drop (FOD) model pl
dc.type JournalArticle pl
dc.abstract.en Abnormal filamentous aggregates that are formed by tangled tau protein turn out to be classic amyloid fibrils, meeting all the criteria defined under the fuzzy oil drop model in the context of amyloid characterization. The model recognizes amyloids as linear structures where local hydrophobicity minima and maxima propagate in an alternating manner along the fibril’s long axis. This distribution of hydrophobicity differs greatly from the classic monocentric hydrophobic core observed in globular proteins. Rather than becoming a globule, the amyloid instead forms a ribbonlike (or cylindrical) structure. pl
dc.subject.en tau amyloid pl
dc.subject.en Alzheimer’s disease pl
dc.subject.en tauopathy pl
dc.description.volume 19 pl
dc.description.number 10 pl
dc.description.points 30 pl
dc.identifier.doi 10.3390/ijms19102910 pl
dc.identifier.eissn 1422-0067 pl
dc.title.journal International Journal of Molecular Sciences pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Zakład Bioinformatyki i Telemedycyny pl
dc.subtype Article pl
dc.identifier.articleid 2910 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 91352
.pointsMNiSW [2018 A]: 30


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Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa