Repozytorium Uniwersytetu Jagiellońskiego

Downregulation of the CXCR4 receptor inhibits cervical carcinoma metastatic behavior in vitro and in vivo

Downregulation of the CXCR4 receptor inhibits cervical ...

Metadane (Dublin Core) Sekuła, Małgorzata [SAP14013842] pl Miękus, Katarzyna [SAP14012939] pl Majka, Marcin [SAP20002206] pl 2015-05-13T08:36:32Z 2015-05-13T08:36:32Z 2014 pl
dc.identifier.issn 1019-6439 pl
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Downregulation of the CXCR4 receptor inhibits cervical carcinoma metastatic behavior in vitro and in vivo pl
dc.type JournalArticle pl
dc.description.physical 1853-1860 pl
dc.abstract.en Cervical carcinoma is frequently diagnosed among women, particularly in low and middle income countries. In this study, we investigated the role of the SDF-1/CXCR4 axis during cervical carcinoma growth and progression in vitro and in vivo. Downregulation of CXCR4 receptor using an RNA interference system led to almost complete inhibition of the receptor expression, activation and function. CXCR4 receptor silencing led to decreased ability to signal, to induce migration and to form holoclone-like colonies, with no influence on viability/proliferation of the cells. CXCR4-deficient cells had also significantly lower levels of MMP-9. Interestingly, downregulation of CXCR4 expression resulted in reduced tumor growth in vivo. Tumors generated by CXCR4-deficient cells had also lower expression of the proliferation marker Ki‑67 and decreased ability to engraft into lungs and spleen. Taken together, our results indicate that CXCR4 receptor may play an important role during cervical carcinoma invasion. In our study CXCR4 influenced invasive properties of cervical carcinoma cells both in vitro and in vivo. pl
dc.subject.en cervical carcinoma pl
dc.subject.en tumor growth pl
dc.subject.en metastasis pl
dc.subject.en CXCR4 pl
dc.description.volume 44 pl
dc.description.number 6 pl
dc.identifier.doi 10.3892/ijo.2014.2383 pl
dc.identifier.eissn 1791-2423 pl
dc.title.journal International Journal of Oncology pl
dc.language.container eng pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biochemii Ogólnej pl
dc.affiliation Wydział Lekarski : Polsko-Amerykański Instytut Pediatrii pl
dc.subtype Article pl
dc.rights.original OTHER; inne; ostateczna wersja wydawcy; po opublikowaniu; 12; pl
.pointsMNiSW [2014 A]: 25

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