The link between periodontal disease and rheumatoid arthritis : an updated review

doi:10.1007/s11926-014-0408-9

The link between periodontal disease and rheumatoid arthritis : an updated review

Communities & Collections

pcg.skipToMenu

The link between periodontal disease and rheumatoid arthritis : an updated review

View Usage Statistics

Show full item record

dc.contributor.author	Kozieł, Joanna [SAP11018189]	pl
dc.contributor.author	Mydel, Piotr [SAP14019835]	pl
dc.contributor.author	Potempa, Jan [SAP11010833]	pl
dc.date.accessioned	2015-05-12T13:55:24Z
dc.date.available	2015-05-12T13:55:24Z
dc.date.issued	2014	pl
dc.identifier.issn	1523-3774	pl
dc.identifier.uri	http://ruj.uj.edu.pl/xmlui/handle/item/6916
dc.language	eng	pl
dc.rights	Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/pl/legalcode	*
dc.title	The link between periodontal disease and rheumatoid arthritis : an updated review	pl
dc.type	JournalArticle	pl
dc.abstract.en	Porphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of the tissues that support the teeth. Recently, the organism has been reported to produce a unique bacterial enzyme, P. gingivalis peptidyl-arginine deiminase (PPAD), which has the ability to convert arginine residues in proteins to citrulline. Protein citrullination alters protein structure and function; hence, PPAD may be involved in deregulation of the host’s signalling network and immune evasion. Further, accumulating evidence suggests a role for autoimmunity against citrullinated proteins in the development of rheumatoid arthritis (RA). As inflammatory conditions in the lungs of cigarette smokers contribute to the breakdown of immune tolerance to citrullinated epitopes, chronic exposure to citrullinated proteins at periodontitis sites may also predispose susceptible individuals to the development of autoantibodies and the initiation of RA. In this review, we discuss evidence that PPAD may represent a mechanistic link between periodontitis and RA, diseases that are known to be significantly associated at the epidemiological level.	pl
dc.subject.en	periodontal disease	pl
dc.subject.en	peptidyl-arginine deiminase (PPAD)	pl
dc.subject.en	P. gingivalis	pl
dc.subject.en	periodontitis	pl
dc.subject.en	PPAD	pl
dc.subject.en	citrullination	pl
dc.subject.en	rheumatoid arthritis	pl
dc.description.volume	16	pl
dc.description.number	3	pl
dc.identifier.doi	10.1007/s11926-014-0408-9	pl
dc.identifier.eissn	1534-6307	pl
dc.title.journal	Current Rheumatology Reports	pl
dc.language.container	eng	pl
dc.affiliation	Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Mikrobiologii	pl
dc.subtype	Article	pl
dc.identifier.articleid	408	pl
dc.rights.original	CC-BY; inne; ostateczna wersja wydawcy; po opublikowaniu; 12;	pl
dc.identifier.project	ROD UJ / P	pl
.pointsMNiSW	[2014 A]: 25