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The link between periodontal disease and rheumatoid arthritis : an updated review

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The link between periodontal disease and rheumatoid arthritis : an updated review

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dc.contributor.author Kozieł, Joanna [SAP11018189] pl
dc.contributor.author Mydel, Piotr [SAP14019835] pl
dc.contributor.author Potempa, Jan [SAP11010833] pl
dc.date.accessioned 2015-05-12T13:55:24Z
dc.date.available 2015-05-12T13:55:24Z
dc.date.issued 2014 pl
dc.identifier.issn 1523-3774 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/6916
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title The link between periodontal disease and rheumatoid arthritis : an updated review pl
dc.type JournalArticle pl
dc.abstract.en Porphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of the tissues that support the teeth. Recently, the organism has been reported to produce a unique bacterial enzyme, P. gingivalis peptidyl-arginine deiminase (PPAD), which has the ability to convert arginine residues in proteins to citrulline. Protein citrullination alters protein structure and function; hence, PPAD may be involved in deregulation of the host’s signalling network and immune evasion. Further, accumulating evidence suggests a role for autoimmunity against citrullinated proteins in the development of rheumatoid arthritis (RA). As inflammatory conditions in the lungs of cigarette smokers contribute to the breakdown of immune tolerance to citrullinated epitopes, chronic exposure to citrullinated proteins at periodontitis sites may also predispose susceptible individuals to the development of autoantibodies and the initiation of RA. In this review, we discuss evidence that PPAD may represent a mechanistic link between periodontitis and RA, diseases that are known to be significantly associated at the epidemiological level. pl
dc.subject.en periodontal disease pl
dc.subject.en peptidyl-arginine deiminase (PPAD) pl
dc.subject.en P. gingivalis pl
dc.subject.en periodontitis pl
dc.subject.en PPAD pl
dc.subject.en citrullination pl
dc.subject.en rheumatoid arthritis pl
dc.description.volume 16 pl
dc.description.number 3 pl
dc.identifier.doi 10.1007/s11926-014-0408-9 pl
dc.identifier.eissn 1534-6307 pl
dc.title.journal Current Rheumatology Reports pl
dc.language.container eng pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Mikrobiologii pl
dc.subtype Article pl
dc.identifier.articleid 408 pl
dc.rights.original CC-BY; inne; ostateczna wersja wydawcy; po opublikowaniu; 12; pl
dc.identifier.project ROD UJ / P pl
.pointsMNiSW [2014 A]: 25


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Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa