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Magnetic resonance imaging in locally advanced rectal cancer : quantitative evaluation of the complete response to neoadjuvant therapy

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Magnetic resonance imaging in locally advanced rectal cancer : quantitative evaluation of the complete response to neoadjuvant therapy

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dc.contributor.author Tarallo, Nicola pl
dc.contributor.author Angeretti, Maria Gloria pl
dc.contributor.author Bracchi, Elena pl
dc.contributor.author Xhepa, Genti pl
dc.contributor.author Molinelli, Valeria pl
dc.contributor.author Tagliaferri, Chiara pl
dc.contributor.author Antognoni, Paolo pl
dc.contributor.author Novario, Raffaele pl
dc.contributor.author Sessa, Fausto pl
dc.contributor.author Fugazzola, Carlo pl
dc.date.accessioned 2019-02-08T11:14:44Z
dc.date.available 2019-02-08T11:14:44Z
dc.date.issued 2018 pl
dc.identifier.issn 1733-134X pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/67957
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/pl/legalcode *
dc.title Magnetic resonance imaging in locally advanced rectal cancer : quantitative evaluation of the complete response to neoadjuvant therapy pl
dc.type JournalArticle pl
dc.description.physical e554-e563 pl
dc.description.additional Bibliogr. s. e562-e563 pl
dc.abstract.en Purpose: To assess the diagnostic performance of diffusion-weighted imaging (DWI) for the discrimination of complete responder (CR) from the non-complete responder (n-CR) in patients with locally advanced rectal cancer (LARC) undergoing chemotherapy and radiation (CRT). Material and methods: Between December 2009 and January 2014, 32 patients (33 lesions: one patient had two synchronous lesions) were enrolled in this retrospective study. All patients underwent a pre- and post-CRT conventional MRI study completed with DWI. For both data sets (T2-weighted and DWI), the pre- and post-CRT tumour volume (VT2; VDWI) and the tumour volume reduction ratio (ΔV%) were determined as well as pre- and post-CRT apparent diffusion coefficient (ADC) and ADC change (ΔADC%). Histopathological findings were the standard of reference. Receiver operating characteristic (ROC) curves were generated to compare performance of T2-weighted and DWI volumetry, as well as ADC. Results: The area under the ROC curve (AUC) revealed a good accuracy of pre- and post-CRT values of VT2 (0.86; 0.91) and VDWI (0.82; 1.00) as well as those of ΔVT2% (0.84) and ΔVDWI% (1.00) for the CR assessment, with no statistical difference. The AUC of pre- and post-CRT ADC (0.53; 0.54) and that of ΔADC% (0.58) were significantly lower. Conclusions: Both post-CRT VDWI and ΔVDWI% (AUC = 1) are very accurate for the assessment of the CR, in spite of no significant differences in comparison to the conventional post-CRT VT2 (AUC = 0.91) and ΔVT2% (AUC = 0.84). On the contrary, both ADC and ΔADC% values are not reliable. pl
dc.subject.en magnetic resonance imaging pl
dc.subject.en diffusion-weighted imaging pl
dc.subject.en rectal cancer pl
dc.subject.en chemoradiation therapy pl
dc.description.volume 83 pl
dc.identifier.doi 10.5114/pjr.2018.81156 pl
dc.identifier.eissn 1899-0967 pl
dc.title.journal Polish Journal of Radiology pl
dc.language.container eng pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa