Repozytorium Uniwersytetu Jagiellońskiego

Does 4-tert-octylphenol affect estrogen signaling pathways in bank vole Leydig cells and tumor mouse Leydig cells in vitro?

Does 4-tert-octylphenol affect estrogen signaling ...

Metadane (Dublin Core)

dc.contributor.author Kotula-Balak, Małgorzata [SAP11018137] pl
dc.contributor.author Chojnacka, Katarzyna [USOS65297] pl
dc.contributor.author Hejmej, Anna [SAP11019511] pl
dc.contributor.author Galas, Jerzy [SAP11006744] pl
dc.contributor.author Satola, Monika pl
dc.contributor.author Bilińska, Barbara [SAP11008023] pl
dc.date.accessioned 2015-04-28T07:02:56Z
dc.date.available 2015-04-28T07:02:56Z
dc.date.issued 2013 pl
dc.identifier.issn 0890-6238 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/5912
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Does 4-tert-octylphenol affect estrogen signaling pathways in bank vole Leydig cells and tumor mouse Leydig cells in vitro? pl
dc.type JournalArticle pl
dc.description.physical 6-16 pl
dc.abstract.en Primary Leydig cells obtained from bank vole testes and the established tumor Leydig cell line (MA-10) have been used to explore the effects of 4-tert-octylphenol (OP). Leydig cells were treated with two concentrations of OP (10(-4) M, 10(-8) M) alone or concomitantly with anti-estrogen ICI 182,780 (1 µM). In OP-treated bank vole Leydig cells, inhomogeneous staining of estrogen receptor alpha (ER alpha) within cell nuclei was found, whereas it was of various intensity among MA-10 Leydig cells. The expression of ER alpha mRNA and protein decreased in both primary and immortalized Leydig cells independently of OP dose. ICI partially reversed these effects at mRNA level while at protein level abrogation was found only in vole cells. Dissimilar action of OP on cAMP and androgen production was also observed. This study provides further evidence that OP shows estrogenic properties acting on Leydig cells. However, its effect is diverse depending on the cellular origin. pl
dc.subject.en 4-tert-octylphenol pl
dc.subject.en Leydig cells pl
dc.subject.en estrogen signaling pl
dc.subject.en bank vole pl
dc.description.volume 39 pl
dc.identifier.doi 10.1016/j.reprotox.2013.03.007 pl
dc.identifier.eissn 1873-1708 pl
dc.title.journal Reproductive Toxicology pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl
dc.pbn.affiliation USOS65297:UJ.WBl; pl
.pointsMNiSW [2013 A]: 35


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