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Does 4-tert-octylphenol affect estrogen signaling pathways in bank vole Leydig cells and tumor mouse Leydig cells in vitro?
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Does 4-tert-octylphenol affect estrogen signaling pathways in bank vole Leydig cells and tumor mouse Leydig cells in vitro?
Bibliographic description
| title: | Does 4-tert-octylphenol affect estrogen signaling pathways in bank vole Leydig cells and tumor mouse Leydig cells in vitro? |
| author: | Kotula-Balak Małgorzata  , Chojnacka Katarzyna , Hejmej Anna , Galas Jerzy , Satola Monika, Bilińska Barbara
|
| journal title: | Reproductive Toxicology |
| volume: | 39 |
| date of publication : | 2013 |
| pages: | 6-16 |
| ISSN: |
0890-6238 |
| eISSN: |
1873-1708 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | Primary Leydig cells obtained from bank vole testes and the established tumor Leydig cell line (MA-10) have been used to explore the effects of 4-tert-octylphenol (OP). Leydig cells were treated with two concentrations of OP (10(-4) M, 10(-8) M) alone or concomitantly with anti-estrogen ICI 182,780 (1 µM). In OP-treated bank vole Leydig cells, inhomogeneous staining of estrogen receptor alpha (ER alpha) within cell nuclei was found, whereas it was of various intensity among MA-10 Leydig cells. The expression of ER alpha mRNA and protein decreased in both primary and immortalized Leydig cells independently of OP dose. ICI partially reversed these effects at mRNA level while at protein level abrogation was found only in vole cells. Dissimilar action of OP on cAMP and androgen production was also observed. This study provides further evidence that OP shows estrogenic properties acting on Leydig cells. However, its effect is diverse depending on the cellular origin. |
| keywords in English: | 4-tert-octylphenol, Leydig cells, estrogen signaling, bank vole |
| affiliation: | Wydział Biologii i Nauk o Ziemi : Instytut Zoologii |
| type: | journal article |
| subtype: | academic paper |
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Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
