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Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats


Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats

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dc.contributor.author Błasiak, Tomasz [SAP11018153] pl
dc.contributor.author Zawadzki, Artur pl
dc.contributor.author Lewandowski, Marian [SAP11009721] pl
dc.date.accessioned 2015-04-27T11:21:17Z
dc.date.available 2015-04-27T11:21:17Z
dc.date.issued 2013 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/5843
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa *
dc.rights.uri http://creativecommons.org/licenses *
dc.title Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats pl
dc.type JournalArticle pl
dc.abstract.en Multiplicity of oscillatory phenomena in a range of infra-slow frequencies (<0.01 Hz) has been described in mammalian brains at different levels of organisation. The significance and manifestation in physiology and/or behaviour of many brain infra-slow oscillations (ISO) remain unknown. Examples of this phenomenon are two types of ISO observed in the brains of urethane-anaesthetised rats: infra-slow, rhythmic changes in the rate of action potential firing in a few nuclei of the subcortical visual system and a sleep-like cycle of activation/deactivation visible in the EEG signal. Because both of these rhythmic phenomena involve brain networks that can influence autonomic nervous system activity, we hypothesised that these two brain ISOs can be reflected by rhythmic changes of pupil size. Thus, in the present study, we used simultaneous pupillography and ECoG recording to verify the hypothesised existence of infra-slow oscillations in the pupil size of urethane-anaesthetised rats. The obtained results showed rhythmic changes in the size of the pupils and rhythmic eyeball movements in urethane-anaesthetised rats. The observed rhythms were characterised by two different dominant components in a range of infra-slow frequencies. First, the long component had a period of ≈29 minutes and was present in both the irises and the eyeball movements. Second, the short component had a period of ≈2 minutes and was observed only in the rhythmic constrictions and dilations of the pupils. Both ISOs were simultaneously present in both eyes, and they were synchronised between the left and right eye. The long ISO component was synchronised with the cyclic alternations of the brain state, as revealed by rhythmic changes in the pattern of the ECoG signal. Based on the obtained results, we propose a model of interference of ISO present in different brain systems involved in the control of pupil size. pl
dc.subject.en lateral geniculate nucleus pl
dc.subject.en olivary pretectal nucleus pl
dc.subject.en intergeniculate leaflet pl
dc.subject.en suprachiasmatic nucleus pl
dc.subject.en light reflex pl
dc.description.volume 8 pl
dc.description.number 4 pl
dc.identifier.doi 10.1371/journal.pone.0062430 pl
dc.identifier.eissn 1932-6203 pl
dc.title.journal PLoS ONE pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.identifier.articleid e62430 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / P pl
.pointsMNiSW [2013 A]: 40

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Udzielam licencji. Uznanie autorstwa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa