Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats

doi:10.1371/journal.pone.0062430

Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats

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Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats

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dc.contributor.author	Błasiak, Tomasz [SAP11018153]	pl
dc.contributor.author	Zawadzki, Artur	pl
dc.contributor.author	Lewandowski, Marian [SAP11009721]	pl
dc.date.accessioned	2015-04-27T11:21:17Z
dc.date.available	2015-04-27T11:21:17Z
dc.date.issued	2013	pl
dc.identifier.uri	http://ruj.uj.edu.pl/xmlui/handle/item/5843
dc.language	eng	pl
dc.rights	Udzielam licencji. Uznanie autorstwa	*
dc.rights.uri	http://creativecommons.org/licenses	*
dc.title	Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats	pl
dc.type	JournalArticle	pl
dc.abstract.en	Multiplicity of oscillatory phenomena in a range of infra-slow frequencies (<0.01 Hz) has been described in mammalian brains at different levels of organisation. The significance and manifestation in physiology and/or behaviour of many brain infra-slow oscillations (ISO) remain unknown. Examples of this phenomenon are two types of ISO observed in the brains of urethane-anaesthetised rats: infra-slow, rhythmic changes in the rate of action potential firing in a few nuclei of the subcortical visual system and a sleep-like cycle of activation/deactivation visible in the EEG signal. Because both of these rhythmic phenomena involve brain networks that can influence autonomic nervous system activity, we hypothesised that these two brain ISOs can be reflected by rhythmic changes of pupil size. Thus, in the present study, we used simultaneous pupillography and ECoG recording to verify the hypothesised existence of infra-slow oscillations in the pupil size of urethane-anaesthetised rats. The obtained results showed rhythmic changes in the size of the pupils and rhythmic eyeball movements in urethane-anaesthetised rats. The observed rhythms were characterised by two different dominant components in a range of infra-slow frequencies. First, the long component had a period of ≈29 minutes and was present in both the irises and the eyeball movements. Second, the short component had a period of ≈2 minutes and was observed only in the rhythmic constrictions and dilations of the pupils. Both ISOs were simultaneously present in both eyes, and they were synchronised between the left and right eye. The long ISO component was synchronised with the cyclic alternations of the brain state, as revealed by rhythmic changes in the pattern of the ECoG signal. Based on the obtained results, we propose a model of interference of ISO present in different brain systems involved in the control of pupil size.	pl
dc.subject.en	lateral geniculate nucleus	pl
dc.subject.en	olivary pretectal nucleus	pl
dc.subject.en	intergeniculate leaflet	pl
dc.subject.en	suprachiasmatic nucleus	pl
dc.subject.en	light reflex	pl
dc.description.volume	8	pl
dc.description.number	4	pl
dc.identifier.doi	10.1371/journal.pone.0062430	pl
dc.identifier.eissn	1932-6203	pl
dc.title.journal	PLoS ONE	pl
dc.language.container	eng	pl
dc.affiliation	Wydział Biologii i Nauk o Ziemi : Instytut Zoologii	pl
dc.subtype	Article	pl
dc.identifier.articleid	e62430	pl
dc.rights.original	CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0;	pl
dc.identifier.project	ROD UJ / P	pl
.pointsMNiSW	[2013 A]: 40