Jagiellonian University Repository

Correlation of CT perfusion and CT volumetry in patients with Alzheimer's disease

pcg.skipToMenu

Correlation of CT perfusion and CT volumetry in patients with Alzheimer's disease

Show full item record

dc.contributor.author Czarnecka, Anna pl
dc.contributor.author Zimny, Anna pl
dc.contributor.author Sąsiadek, Marek pl
dc.date.accessioned 2018-10-10T14:15:37Z
dc.date.available 2018-10-10T14:15:37Z
dc.date.issued 2010 pl
dc.identifier.issn 1733-134X pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/57814
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/pl/legalcode *
dc.title Correlation of CT perfusion and CT volumetry in patients with Alzheimer's disease pl
dc.type JournalArticle pl
dc.description.physical 15-21 pl
dc.description.additional Bibliogr. s. 20-21 pl
dc.identifier.weblink http://archiwum.polradiol.com/download/index/idArt/878511.html pl
dc.abstract.en Background: Both brain atrophy and decrease of perfusion are observed in dementive diseases. The aim of the study was to correlate the results of brain perfusion CT (pCT) and CT volumetry in patients with Alzheimer's disease (AD). Material/Methods: Forty-eight patients with AD (mean age of 71.3 years) underwent brain pCT and CT volumetry. The pCT was performed at the level of basal ganglia after the injection of contrast medium (50 ml, 4 ml/ sec.) with serial scanning (delay 7 sec, 50 scans, 1 scan/sec). Volumetric measurements were carried out on the basis of source images, with the use of a dedicated CT software combined with manual outlining of the regions of interest in extracerebral and intraventricular CSF spaces. Perfusion parameters of the cerebral blood flow (CBF) and cerebral blood volume (CBV) from the grey matter of frontal and temporal as well as basal ganglia were compared statistically with the volumetric measurements of frontal and temporal cortical atrophy as well as subcortical atrophy. Results: A statistically significant positive correlation was found between the values of CBF and CBV in the basal ganglia and the volumes of the lateral and third ventricles. The comparison of CBF and CBV results with the volumetric measurements in the areas of the frontal and temporal lobes showed mostly negative correlations, but none of them was of statistical significance. Conclusions: In patients with AD, the degree of cortical atrophy is not correlated with the decrease of perfusion in the grey matter and subcortical atrophy is not correlated with the decrease of perfusion in the basal ganglia region. It suggests that functional and structural changes in AD are not related to each other. pl
dc.subject.en Alzheimer's disease pl
dc.subject.en CT perfusion pl
dc.subject.en CT volumetry pl
dc.description.volume 75 pl
dc.description.number 2 pl
dc.identifier.eissn 1899-0967 pl
dc.title.journal Polish Journal of Radiology pl
dc.language.container eng pl
dc.date.accession 2018-10-10 pl
dc.subtype Article pl
dc.identifier.articleid 878511 pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl


Files in this item

This item appears in the following Collection(s)

Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa