Jagiellonian University Repository

Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder : a systematic review

Interactions between variation in candidate genes ...

Show full item record

dc.contributor.author Misiak, Błażej pl
dc.contributor.author Stramecki, Filip pl
dc.contributor.author Gawęda, Łukasz pl
dc.contributor.author Prochwicz, Katarzyna [SAP11018741] pl
dc.contributor.author Sąsiadek, Maria M pl
dc.contributor.author Mustafa, Ahmed A pl
dc.contributor.author Frydecka, Dorota pl
dc.date.accessioned 2018-09-13T12:10:10Z
dc.date.available 2018-09-13T12:10:10Z
dc.date.issued 2018 pl
dc.identifier.issn 0893-7648 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/56941
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder : a systematic review pl
dc.type JournalArticle pl
dc.description.physical 5075 -5100 pl
dc.identifier.weblink https://link.springer.com/content/pdf/10.1007%2Fs12035-017-0708-y.pdf pl
dc.abstract.en Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with high heritability rates. The contribution of genetic factors to the etiology of these disorders is increasingly being recognized as the action of multiple risk variants with small effect sizes, which might explain only a minor part of susceptibility. On the other site, numerous environmental factors have been found to play an important role in their causality. Therefore, in recent years, several studies focused on gene × environment interactions that are believed to bridge the gap between genetic underpinnings and environmental insults. In this article, we performed a systematic review of studies investigating gene × environment interactions in BD and schizophrenia spectrum phenotypes. In the majority of studies from this field, interacting effects of variation in genes encoding catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF), and FK506-binding protein 5 (FKBP5) have been explored. Almost consistently, these studies revealed that polymorphisms in COMT, BDNF, and FKBP5 genes might interact with early life stress and cannabis abuse or dependence, influencing various outcomes of schizophrenia spectrum disorders and BD. Other interactions still require further replication in larger clinical and non-clinical samples. In addition, future studies should address the direction of causality and potential mechanisms of the relationship between gene × environment interactions and various categories of outcomes in schizophrenia and BD. pl
dc.subject.en psychosis pl
dc.subject.en gene polymorphism pl
dc.subject.en bipolarity pl
dc.subject.en gene × environment interaction pl
dc.description.volume 55 pl
dc.description.number 6 pl
dc.identifier.eissn 1559-1182 pl
dc.title.journal Molecular Neurobiology pl
dc.language.container eng pl
dc.date.accession 2018-09-12 pl
dc.affiliation Wydział Filozoficzny : Instytut Psychologii pl
dc.subtype Article pl
dc.rights.original CC-BY; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl


Files in this item

This item appears in the following Collection(s)

Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa