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Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex

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Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex

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dc.contributor.author Jasińska, Małgorzata [SAP20012228] pl
dc.contributor.author Siucińska, Ewa pl
dc.contributor.author Jasek, Ewa pl
dc.contributor.author Litwin, Jan [SAP20000544] pl
dc.contributor.author Pyza, Elżbieta [SAP11010854] pl
dc.contributor.author Kossut, Małgorzata pl
dc.date.accessioned 2015-04-22T09:10:17Z
dc.date.available 2015-04-22T09:10:17Z
dc.date.issued 2013 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/5451
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa *
dc.rights.uri http://creativecommons.org/licenses *
dc.title Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex pl
dc.type JournalArticle pl
dc.abstract.en Associative fear learning, resulting from whisker stimulation paired with application of a mild electric shock to the tail in a classical conditioning paradigm, changes the motor behavior of mice and modifies the cortical functional representation of sensory receptors involved in the conditioning. It also induces the formation of new inhibitory synapses on double-synapse spines of the cognate barrel hollows. We studied density and distribution of polyribosomes, the putative structural markers of enhanced synaptic activation, following conditioning. By analyzing serial sections of the barrel cortex by electron microscopy and stereology, we found that the density of polyribosomes was significantly increased in dendrites of the barrel activated during conditioning. The results revealed fear learning-induced increase in the density of polyribosomes associated with both excitatory and inhibitory synapses located on dendritic spines (in both single- and double-synapse spines) and only with the inhibitory synapses located on dendritic shafts. This effect was accompanied by a significant increase in the postsynaptic density area of the excitatory synapses on single-synapse spines and of the inhibitory synapses on double-synapse spines containing polyribosomes. The present results show that associative fear learning not only induces inhibitory synaptogenesis, as demonstrated in the previous studies, but also stimulates local protein synthesis and produces modifications of the synapses that indicate their potentiation. pl
dc.description.volume 8 pl
dc.description.number 2 pl
dc.description.points 40 pl
dc.identifier.doi 10.1371/journal.pone.0054301 pl
dc.identifier.eissn 1932-6203 pl
dc.title.journal PLoS ONE pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.affiliation Wydział Lekarski : Zakład Histologii pl
dc.subtype Article pl
dc.identifier.articleid e54301 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / P pl
dc.cm.id 58545
.pointsMNiSW [2013 A]: 40


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Udzielam licencji. Uznanie autorstwa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa