Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex

doi:10.1371/journal.pone.0054301

Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex

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Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex

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dc.contributor.author	Jasińska, Małgorzata [SAP20012228]	pl
dc.contributor.author	Siucińska, Ewa	pl
dc.contributor.author	Jasek, Ewa	pl
dc.contributor.author	Litwin, Jan [SAP20000544]	pl
dc.contributor.author	Pyza, Elżbieta [SAP11010854]	pl
dc.contributor.author	Kossut, Małgorzata	pl
dc.date.accessioned	2015-04-22T09:10:17Z
dc.date.available	2015-04-22T09:10:17Z
dc.date.issued	2013	pl
dc.identifier.uri	http://ruj.uj.edu.pl/xmlui/handle/item/5451
dc.language	eng	pl
dc.rights	Udzielam licencji. Uznanie autorstwa	*
dc.rights.uri	http://creativecommons.org/licenses	*
dc.title	Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex	pl
dc.type	JournalArticle	pl
dc.abstract.en	Associative fear learning, resulting from whisker stimulation paired with application of a mild electric shock to the tail in a classical conditioning paradigm, changes the motor behavior of mice and modifies the cortical functional representation of sensory receptors involved in the conditioning. It also induces the formation of new inhibitory synapses on double-synapse spines of the cognate barrel hollows. We studied density and distribution of polyribosomes, the putative structural markers of enhanced synaptic activation, following conditioning. By analyzing serial sections of the barrel cortex by electron microscopy and stereology, we found that the density of polyribosomes was significantly increased in dendrites of the barrel activated during conditioning. The results revealed fear learning-induced increase in the density of polyribosomes associated with both excitatory and inhibitory synapses located on dendritic spines (in both single- and double-synapse spines) and only with the inhibitory synapses located on dendritic shafts. This effect was accompanied by a significant increase in the postsynaptic density area of the excitatory synapses on single-synapse spines and of the inhibitory synapses on double-synapse spines containing polyribosomes. The present results show that associative fear learning not only induces inhibitory synaptogenesis, as demonstrated in the previous studies, but also stimulates local protein synthesis and produces modifications of the synapses that indicate their potentiation.	pl
dc.description.volume	8	pl
dc.description.number	2	pl
dc.description.points	40	pl
dc.identifier.doi	10.1371/journal.pone.0054301	pl
dc.identifier.eissn	1932-6203	pl
dc.title.journal	PLoS ONE	pl
dc.language.container	eng	pl
dc.affiliation	Wydział Biologii i Nauk o Ziemi : Instytut Zoologii	pl
dc.affiliation	Wydział Lekarski : Zakład Histologii	pl
dc.subtype	Article	pl
dc.identifier.articleid	e54301	pl
dc.rights.original	CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0;	pl
dc.identifier.project	ROD UJ / P	pl
dc.cm.id	58545
.pointsMNiSW	[2013 A]: 40