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Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)

Porphyromonas gingivalis facilitates the development ...

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dc.contributor.author Maresz, Katarzyna [SAP12020021] pl
dc.contributor.author Hellvard, Annelie pl
dc.contributor.author Sroka, Aneta [SAP12117031] pl
dc.contributor.author Adamowicz, Karina [SAP14001568] pl
dc.contributor.author Bielecka, Ewa [USOS61857] pl
dc.contributor.author Kozieł, Joanna [SAP11018189] pl
dc.contributor.author Gawron, Katarzyna [SAP14002828] pl
dc.contributor.author Mizgalska, Danuta [SAP12020224] pl
dc.contributor.author Marcińska, Katarzyna [SAP20008807] pl
dc.contributor.author Benedyk, Małgorzata [SAP14000434] pl
dc.contributor.author Pyrć, Krzysztof [SAP11019543] pl
dc.contributor.author Quirke, Anne-Marie pl
dc.contributor.author Jonsson, Roland pl
dc.contributor.author Alzabin, Saba pl
dc.contributor.author Venables, Patrick J. pl
dc.contributor.author Nguyen, Ky-Anh pl
dc.contributor.author Mydel, Piotr [SAP14019835] pl
dc.contributor.author Potempa, Jan [SAP11010833] pl
dc.date.accessioned 2015-04-20T09:41:45Z
dc.date.available 2015-04-20T09:41:45Z
dc.date.issued 2013 pl
dc.identifier.issn 1553-7366 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/5275
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa *
dc.rights.uri https://creativecommons.org/licenses *
dc.title Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD) pl
dc.type JournalArticle pl
dc.abstract.en Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in humans and are associated with each other both clinically and epidemiologically. Recent findings suggest a causative link between periodontal infection and rheumatoid arthritis via bacteria-dependent induction of a pathogenic autoimmune response to citrullinated epitopes. Here we showed that infection with viable periodontal pathogen Porphyromonas gingivalis strain W83 exacerbated collagen-induced arthritis (CIA) in a mouse model, as manifested by earlier onset, accelerated progression and enhanced severity of the disease, including significantly increased bone and cartilage destruction. The ability of P. gingivalis to augment CIA was dependent on the expression of a unique P. gingivalis peptidylarginine deiminase (PPAD), which converts arginine residues in proteins to citrulline. Infection with wild type P. gingivalis was responsible for significantly increased levels of autoantibodies to collagen type II and citrullinated epitopes as a PPAD-null mutant did not elicit similar host response. High level of citrullinated proteins was also detected at the site of infection with wild-type P. gingivalis. Together, these results suggest bacterial PAD as the mechanistic link between P. gingivalis periodontal infection and rheumatoid arthritis. pl
dc.description.volume 9 pl
dc.description.number 9 pl
dc.identifier.doi 10.1371/journal.ppat.1003627 pl
dc.identifier.eissn 1553-7374 pl
dc.title.journal PLOS Pathogens pl
dc.language.container eng pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Mikrobiologii pl
dc.affiliation Wydział Nauk o Zdrowiu : Instytut Pielęgniarstwa i Położnictwa pl
dc.subtype Article pl
dc.identifier.articleid e1003627 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / P pl
dc.pbn.affiliation USOS61857:UJ.WBt; pl
.pointsMNiSW [2013 A]: 45


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Udzielam licencji. Uznanie autorstwa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa