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Quantitative computed tomography (CT) assessment of emphysema in patients with severe chronic obstructive pulmonary disease (COPD) and its correlation with age, sex, pulmonary function tests, BMI, smoking, and biomass exposure

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Quantitative computed tomography (CT) assessment of emphysema in patients with severe chronic obstructive pulmonary disease (COPD) and its correlation with age, sex, pulmonary function tests, BMI, smoking, and biomass exposure

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dc.contributor.author Shaikh, Minhaj pl
dc.contributor.author Sood, Ram Gopal pl
dc.contributor.author Sarkar, Malay pl
dc.contributor.author Thakur, Vijay pl
dc.date.accessioned 2018-01-05T11:24:05Z
dc.date.available 2018-01-05T11:24:05Z
dc.date.issued 2017 pl
dc.identifier.issn 1733-134X pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/48094
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode *
dc.title Quantitative computed tomography (CT) assessment of emphysema in patients with severe chronic obstructive pulmonary disease (COPD) and its correlation with age, sex, pulmonary function tests, BMI, smoking, and biomass exposure pl
dc.type JournalArticle pl
dc.description.physical 760-766 pl
dc.description.additional Bibliogr. s. 765-766 pl
dc.abstract.en Background: To evaluate the role of HRCT in quantifying emphysema in severe COPD patients and to study the variations in the pattern of emphysema in relation to age, sex, FEV1, smoking index, biomass exposure, and BMI. Material/Methods: Automatic lung segmentation of HRCT scans in 41 severe COPD patients (GOLD stage III or more) was done using an emphysema protocol. The extent of emphysema was assessed using the density mask method with a threshold of -950 HU (%LAA-950). The percentage of emphysema in each lung lobe and both lungs was correlated with 6 parameters - age, sex, BMI, smoking index, biomass exposure, and FEV1. Results: Smoking resulted in homogenously distributed emphysema regardless of the severity of smoking. BMI was inversely correlated with the extent of emphysema. A significant association was found between the percentage of emphysema in the right lower lobe and BMI (P=0.015), between biomass exposure and the percentage of emphysema in RUL, RLL, and both lungs (P values of 0.024, 0.016, and 0.036, respectively). The extent of emphysema was disproportionately low compared to the amount of obstruction on PFTs, indicating an airway predominant variety of COPD with significant biomass exposure. Conclusions: Smoking is associated with a relatively homogenous distribution of emphysema with no regional predilection. Biomass exposure produces predominantly right-sided emphysema. BMI decreases with increasing levels of emphysema in the right lower lobe. These risk factors of emphysema patterns are helpful in deciding on the management, including surgical options. pl
dc.subject.en emphysema pl
dc.subject.en pulmonary disease pl
dc.subject.en chronic obstructive pl
dc.subject.en smoking pl
dc.subject.en tomography pl
dc.subject.en spiral computed pl
dc.description.volume 82 pl
dc.identifier.doi 10.12659/PJR.903278 pl
dc.identifier.eissn 1899-0967 pl
dc.title.journal Polish Journal of Radiology pl
dc.language.container eng pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska