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Dissecting medial temporal lobe contributions to item and associative memory formation

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Dissecting medial temporal lobe contributions to item and associative memory formation

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dc.contributor.author Qin, S. pl
dc.contributor.author Rijpkema, M pl
dc.contributor.author Tendolkar, I pl
dc.contributor.author Piekema, C pl
dc.contributor.author Hermans, E pl
dc.contributor.author Binder, Marek [SAP11018111] pl
dc.contributor.author Petersson, K. M. pl
dc.contributor.author Luo, J. pl
dc.contributor.author Fernandez, G pl
dc.date.accessioned 2017-12-12T11:39:17Z
dc.date.available 2017-12-12T11:39:17Z
dc.date.issued 2009 pl
dc.identifier.issn 1053-8119 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/47533
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Dissecting medial temporal lobe contributions to item and associative memory formation pl
dc.type JournalArticle pl
dc.description.physical 874-881 pl
dc.abstract.en A fundamental and intensively discussed question is whether medial temporal lobe (MTL) processes that lead to non-associative item memories differ in their anatomical substrate from processes underlying associative memory formation. Using event-related functional magnetic resonance imaging, we implemented a novel design to dissociate brain activity related to item and associative memory formation not only by subsequent memory performance and anatomy but also in time, because the two constituents of each pair to be memorized were presented sequentially with an intra-pair delay of several seconds. Furthermore, the design enabled us to reduce potential differences in memory strength between item and associative memory by increasing task difficulty in the item recognition memory test. Confidence ratings for correct item recognition for both constituents did not differ between trials in which only item memory was correct and trials in which item and associative memory were correct. Specific subsequent memory analyses for item and associative memory formation revealed brain activity that appears selectively related to item memory formation in the posterior inferior temporal, posterior parahippocampal, and perirhinal cortices. In contrast, hippocampal and inferior prefrontal activity predicted successful retrieval of newly formed inter-item associations. Our findings therefore suggest that different MTL subregions indeed play distinct roles in the formation of item memory and inter-item associative memory as expected by several dual process models of the MTL memory system. pl
dc.subject.en episodic memory pl
dc.subject.en parahippocampal cortex pl
dc.subject.en hippocampus pl
dc.subject.en perirhinal cortex pl
dc.subject.en prefrontal cortex pl
dc.description.volume 46 pl
dc.description.number 3 pl
dc.identifier.doi 10.1016/j.neuroimage.2009.02.039 pl
dc.identifier.eissn 1095-9572 pl
dc.title.journal NeuroImage pl
dc.language.container eng pl
dc.affiliation Wydział Filozoficzny : Instytut Psychologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl


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